grant
Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 11 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025AblationAbscissionAddressAreaArtifactsBiochemicalBiopsyBlood SerumBlood VesselsCK MiMiCRISPRCRISPR/Cas systemCancer CauseCancer EtiologyCancer ModelCancerModelCancersCell BodyCellsCessation of lifeCharacteristicsChemicalsClinicalClinical ManagementClustered Regularly Interspaced Short Palindromic RepeatsCollectionCreatineCreatine PhosphateCurative SurgeryCytosolDeathDevelopmentDiagnosisDiagnosticDifferential DisplayDiffusionEngineeringEvaluationExcisionExtirpationFamily suidaeFundingGene TargetingGeneralized GrowthGenesGenetic HeterogeneityGoalsGrantGrowthHepatic CancerHepatocarcinomaHepatocarcinoma modelHepatocellular CarcinomaHepatocellular cancerHepatomaHeterogeneityHumanImageImaging ProceduresImaging TechnicsImaging TechniquesIn VitroIntermediary MetabolismIntratumoral heterogeneityInvadedKRAS(G12D)KRASG12DKineticsKnock-outKnockoutKnowledgeLiverLiver Cells CarcinomaLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMapsMeasurementMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic ProcessesMetabolismModern ManMolecularMolecular FingerprintingMolecular ProfilingMonitorMorphologic artifactsMotionNMR ImagingNMR TomographyNatural regenerationNoduleNuclear Magnetic Resonance ImagingOncopigPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPerformancePhosphocreatinePhosphorylcreatinePigsPopulationPrimary Malignant Neoplasm of LiverPrimary carcinoma of the liver cellsPrimary liver cancerPrognosisProliferatingProtocolProtocols documentationRF ablationRadio Frequency AblationRadiofrequency AblationRadiofrequency Interstitial AblationRecurrenceRecurrentRegenerationRemovalResolutionRespirationRisk AssessmentSensitivity and SpecificitySerumSuidaeSurgical RemovalSurvival RateSwineSystemTechniquesTestingTherapeuticTissue GrowthTransgenic OrganismsTumor BiologyTumor BurdenTumor LoadZeugmatographycancer cell metabolismcancer metabolismcancer progressionclinical practiceclinical relevanceclinically relevantdevelopmentaldiagnostic biomarkerdiagnostic markerdiagnostic tooldifferential display techniquediffuseddiffusesdiffusingdiffusionseffective therapyeffective treatmentempowermentgenetic profilinghepatic body systemhepatic organ systemhepatocellular carcinoma cancer modelhepatocellular carcinoma modelheterogeneity in tumorsimagingimprovedin vivoinnovateinnovationinnovativeinsightintra-tumoral heterogeneityintrahepaticintratumor heterogeneityknock-downknockdownliver cancerliver cancer modelliver cancer patientliver carcinomaliver malignancymRNA Differential Displaysmalignancymalignant liver tumormigrationmitochondrial creatine kinasemolecular profilemolecular signaturemultidisciplinaryneoplasm progressionneoplasm/cancerneoplastic progressionnon-invasive imagingnoninvasive imagingontogenyoverexpressoverexpressionpatient oriented outcomespatient prognosispig modelpiglet modelporcineporcine modelprognostic toolregenerateresearch studyresectionresolutionsrespiratoryrespiratory mechanismresponse to therapyresponse to treatmentrisk stratificationstratify risksuidswine modeltherapeutic responsetherapeutic stratificationtherapy responsetransgenictreatment responsetreatment responsivenesstreatment stratificationtumortumor cell metabolismtumor growthtumor heterogeneitytumor metabolismtumor progressionvascular
Description preview
PROJECT ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive malignancy representing the 7th most
common cancer globally and the 4th most common cause of cancer death worldwide. Although magnetic
resonance imaging (MRI) represents a common HCC diagnostic and prognostic tool, MRI fails to provide insights
into HCC risk stratification, and does…
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