grant
Noncanonical roles of Bim in heat shock-induced cell death
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 15 Aug 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AdiaphoresisAmphetaminesAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAnhidrosisAnti-CholinergicsAnticholinergic AgentsAnticholinergicsApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Gene Caspase 2ApoptoticB cell lymphoma 2B-Cell CLL/Lymphoma 2 GeneB-cell lymphoma/leukemia-2BCL2BCL2 geneBH3 DomainBH3 Interacting Domain Death AgonistBH3 interacting domain death agonist proteinBID proteinBasal Transcription FactorBasal transcription factor genesBcl-2BindingBiologyBody SystemBody TemperatureBody Temperature RegulationBody ThermoregulationBody TissuesCASP-2CASP2CASP2 geneCATLCTSL ProteinCancersCaspase-2 GeneCathepsin LCathepsinsCell BodyCell CycleCell DeathCell Death InductionCell Death SignalingCell Death Signaling ProcessCell Division CycleCell Membrane PermeabilityCell NucleusCellsClinicComplexCytoplasmDNA mutationDataDesoxynorephedrinDiseaseDisorderDiureticsDrugsDyneinDynein ATPaseDynein Adenosine TriphosphataseDynein AdenosinetriphosphataseExertionExhibitsExocytosisExposure toExtracellular SpaceFailureFamily memberGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic defectGenetic mutationGoalsHeat ShockHeat StrokeHeat-Shock ReactionHeat-Shock ResponseHeatstrokeHigh temperature of physical objectHistone H3.3HyperthermiaHypohidrosisICH-1 Protease GeneICH-1LICH-1L/1SICH1Ich-1 proteinIntercellular SpaceKnock-outKnockoutLipidsLocal HyperthermiaLysosomesMajor Excreted ProteinMalignant NeoplasmsMalignant TumorMediatingMedicationModelingMolecular InteractionMotorMutant Strains MiceMutationNEDD2NEDD2 Apoptosis Regulatory GeneNedd-2 proteinNuclearNucleusOrgan SystemOrgan failurePathway interactionsPatientsPeripheralPermeabilityPharmaceutical PreparationsPhenaminePhenoprominPhysical activityPhysiologic ThermoregulationPlayPositionPositioning AttributePredispositionProcessProgrammed Cell DeathProteinsRegulationReportingResistanceRiskRoleSusceptibilityTemperatureThermoregulationTissuesTranscription Factor Proto-OncogeneTranscription factor genesbcl-2 Genescaspase-2ced9 homologclimate changeclimatic changescystatin Bdl-Amphetaminedrug/agentdynein light chaingenome mutationglobal climate changehigh temperaturein vivoinhibitorinsightmalignancymembrane permeabilitymouse modelmouse mutantmurine modelmutantmutant mouse modelnecrocytosisneoplasm/cancernovelpathwayresistantresponsesocial rolestefinstefin Proteinase inhibitortraffickingtranscription factortumor
Description preview
PROJECT SUMMARY/ABSTRACT
Severe hyperthermia (heatstroke) is due to a failure of thermoregulation that can lead to cell death in various
tissues resulting in multisystem organ failure. Hyperthermia generally results from overexertion due to severe
physical activity and/or prolonged exposure to elevated temperatures. Patients who suffer from…
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