grant
Noncanonical glutamate signaling in the origins of the migraine attack
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 15 Aug 2017Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20262-photonAddressAffectAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAstrocytesAstrocytusAstrogliaAurasAwardBiologic ModelsBiological ModelsBrainBrain Nervous SystemCalciumCell Communication and SignalingCell SignalingCerebral cortexCharacteristicsCommunicationDataDiffusionDiseaseDisorderElectrophysiologyElectrophysiology (science)EncephalonEventExposure toExtracellular SpaceFailureFeedbackGenerationsGlutamatesHumanImageImpairmentIntercellular SpaceIntracellular Communication and SignalingK elementL-GlutamateLeadLeao depressionLearningMeasurableMeasurementMediatorMigraineMigraine HeadacheModel SystemModern ManNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeural TransmissionNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurophysiology / ElectrophysiologyPainPainfulPb elementPersonsPhysiologicPhysiologicalPhysiologyPopulationPotassiumPredispositionProcessResolutionScanningSensory HallucinationsShapesSignal TransductionSignal Transduction SystemsSignalingSourceSpreading Cortical DepressionSusceptibilitySynapsesSynapticSynaptic TransmissionTechniquesTestingTropismWhole-Cell RecordingsWorkanimationastrocytic gliabarrel cortexbiological signal transductionbrain tissuecell typediffuseddiffusesdiffusingdiffusionsdisabilityelectrophysiologicalextracellulargene manipulationgenetic manipulationgenetically manipulategenetically perturbglutamate signalingglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalingheavy metal Pbheavy metal leadimagingin vivoinsightmodel of animalneural mechanismneurological diseaseneuromechanismneuronalnovelpostsynapticpreferenceresolutionsreuptakesensory cortexsynapsetwo-photonuptakevesicle releasevesicular releasevoltage
Description preview
PROJECT SUMMARY/ABSTRACT
Migraine affects 15% of the world population, and is one of the leading causes of disability worldwide. Yet
surprisingly little is known about the basic features of this disease. One of the major questions in migraine is
how its quintessential feature, the migraine attack, is generated. For approximately a third of…
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