grant
Non-Templated Regulation of IgE Mediated Anaphylaxis
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 16 Nov 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202521+ years old7S Gamma GlobulinAbscissionAcylneuraminyl hydrolaseAdultAdult HumanAffectAffinityAllergensAllergicAllergic DiseaseAllergic inflammationAllergic to foodAllergyAllergy to foodAllergy to peanutsAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAntibodiesAntigenic DeterminantsAttenuatedBasophilic GranulocyteBasophilsBindingBinding DeterminantsBiochemistryBiological ChemistryBiological MarkersBiologyBiophysicsBlood BasophilCell Communication and SignalingCell CountCell NumberCell SignalingCellular ImmunologyClinicalCo-ImmunoprecipitationsComplexDataDiseaseDisorderEngineeringEpitopesExcisionExpression SignatureExtirpationFoodFood AllergyFood HypersensitivityGene Expression ProfileGenetic ScreeningGlycansGlycobiologyGlycoengineeringGlycoproteinsGoalsGroundnut HypersensitivityIgEIgGImmune responseImmunoglobulin EImmunoglobulin GImmunologyIn VitroIndividualInflammationInsect ProteinsIntracellular Communication and SignalingKnowledgeLinkLupus Erythematosus DisseminatusMarrow Mast CellMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMediatorMetabolic GlycosylationMissionModelingMolecular ImmunologyMolecular InteractionN-Acetylneuraminic AcidsN-Acylneuraminate GlycohydrolasesNational Institutes of HealthNeuraminidaseOligosaccharide SialidaseOutcomePathogenicityPathway interactionsPatternPeanut HypersensitivityPlayPolysaccharidesPopulationPublic HealthReceptor ProteinRegulationRegulatory PathwayRemovalResearchRoleSLESialic AcidsSialidaseSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStructureSurgical RemovalSymptomsSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTestingTherapeuticTissue BasophilsUnited States National Institutes of HealthWritingadulthoodallergic reaction to peanutallergic response to peanutallergic to peanutsanti-IgEanti-IgEidarmattenuateattenuatesattenuationbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker discoverybiophysical foundationbiophysical principlesbiophysical sciencescrosslinkdisseminated lupus erythematosusexo alpha sialidaseexperimentexperimental researchexperimental studyexperimentsgene expression patterngene expression signatureglycosylationhelminth infectionhelminthic infectionhost responsehuman modelimmune system responseimmunoresponsein vivoinfected with helminthmast cellmastocytemodel of humanmouse modelmurine modelnew drug targetnew druggable targetnew markernew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel biomarkernovel drug targetnovel druggable targetnovel markernovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypeanut allergicpeanut allergyreceptorresectionsialylationsocial rolesugarsystemic lupus erythematosistranscriptional profiletranscriptional signaturetranslational impact
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Project Summary/Abstract
It is not clear why some individuals with allergen-specific IgE suffer from allergies, while others do not. It is likely
that multiple factors contribute, including differences in IgE affinity or epitope diversity for allergens, mast cell
numbers, FceRI expression levels, Syk signaling, allergen-specific IgG antibodies,…
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