grant
Non-invasive Monitoring for Infections and Rejection after Lung Transplantation
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 20 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025Airway infectionsAllograftingAntimicrobial ResistanceAreaBacteriaBacteriophagesBar CodesBiological MarkersBlood PlasmaBlood SampleBlood specimenBody TissuesBronchoalveolar Lavage FluidCaringCell BodyCellsCharacteristicsChronicCohort StudiesCommunicable DiseasesConcurrent StudiesDNADNA VirusesDataDeoxyribonucleic AcidDiagnosisDiagnosticDictionaryExplosionGenus MycobacteriumGraft RejectionHealthHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHumanImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostInfectionInfectious DiseasesInfectious DisorderLifeLong-term cohortLong-term cohort studyLongitudinal cohortLongitudinal cohort studyLungLung GraftingLung Respiratory SystemLung TransplantationLung infectionsMedicineModern ManMonitorMycobacteriumNGS MethodNGS systemOrganismParasitesPatient MonitoringPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhagesPhenotypePlasmaPlasma SerumPneumoniaPopulation DynamicsProceduresProtocolProtocols documentationPulmonary GraftPulmonary TransplantPulmonary TransplantationRespiratory InfectionsRespiratory Tract InfectionsRespiratory infectious agentRespiratory tract pathogenReticuloendothelial System, Serum, PlasmaSamplingSpecificitySymptomsTechnologyTestingTimeTissuesTransplant RecipientsTransplant RejectionTransplantation RejectionVariantVariationViralVirusWorkallograft rejectionanti-microbial resistantanti-microbial resistant pathogenantimicrobial resistant pathogenbacterial virusbarcodebio-markersbiologic markerbiomarkercell free DNAcell free circulating DNAcolonization associated with lungcolonization in the lungcolonization within the lungdiagnostic approachdiagnostic strategyfecal samplefungusimmunosuppressed patientinnovateinnovationinnovativeinsightinterestliving systemlung colonizationlung transplantmicrobe pathogenmicrobialmicrobial pathogenmycobacterialnew approachesnext gen sequencingnext generation sequencingnextgen sequencingnon-invasive diagnosisnon-invasive diagnosticnon-invasive monitornoninvasive diagnosisnoninvasive diagnosticnoninvasive monitornovelnovel approachesnovel strategiesnovel strategypathogenpathogenic microbepatient oriented outcomesperipheral bloodprospectivepulmonary colonizationpulmonary infectionsresistance strainresistance to anti-microbialresistant strainresistant to antimicrobialrespiratoryrespiratory allograftrespiratory pathogenstool samplestool specimentransplant patient
Description preview
Project Summary
Over 4,000 patients receive life-saving lung transplants every year. Unfortunately, chronic respiratory
infection frequently complicates these cases and undermines the long-term benefits of this procedure. However,
it can be difficult to identify infections early or to distinguish them from rejection. Unfortunately, the current…
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