Non-Heme Enzymes as Biocatalytic Platform for the Production of Heterocycles
Description preview
In this proposal, we will develop novel biocatalytic reactions using Fe and alpha-ketoglutarate dependent enzymes (aKGs). We will exploit the mechanistic diversity of these enzymes to design reactions that are exceptionally challenging for traditional chemical catalysts. In particular, we will transform aKGs into a synthetically useful platform…
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