grant
Non-canonical transcriptional activation of MITF in pigment cells.
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20263'5'-cyclic ester of AMPATF-1ATF1AblationAddressAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)Artificial skinB16F10Basal Transcription FactorBasal transcription factor genesBindingBiologicalBiologyBody TissuesBone DevelopmentCREBCREB1CREB1 geneCell BodyCell Communication and SignalingCell Growth in NumberCell LineCell MultiplicationCell NucleusCell ProliferationCell SignalingCell modelCellLineCellsCellular ProliferationCellular modelChemopreventionChromatinComplexCoupledCyclic AMPCyclic AMP-Dependent Protein KinasesDNADNA DamageDNA InjuryDNA Molecular BiologyDeoxyribonucleic AcidDiseaseDisorderEngineeringEventFoundationsGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene ModifiedGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic ScreeningGenetic TranscriptionGoalsGrowthImmunoblottingIndividualInflammationIntracellular Communication and SignalingIsoformsKnock-outKnockoutMalignant Skin NeoplasmMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMelanoma CellModificationMolecularMolecular AnalysisMolecular BiologyMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsNucleusOrganoidsPKAPathway interactionsPhosphorylationPhysiologicPhysiologicalPhysiologyPigmentationPigmentation DisordersPigmentation physiologic functionPigmentsPlayPreventiveProcessProductionProtein IsoformsProtein Kinase AProtein PhosphorylationProtocolProtocols documentationRNA ExpressionReceptor ProteinRegulationReporterResearchRoleSeasonsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSkin AgingSkin CancerSkin Pigmentation DisorderSkin tanningStrains Cell LinesSunburnSunlightTanningTestingTherapeuticTimeTissue GrowthTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription ActivationTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationTranscriptional Activator/CoactivatorTranscriptional ControlTranscriptional RegulationUV damageUV induced damageUpregulationWestern BlottingWestern ImmunoblottingWorkactivating transcription factor 1adenosine 3'5' monophosphateaged skinanalyze gene expressionbiologicbiological signal transductionblood glucose regulationcAMPcAMP Response Element-Binding Protein 1cAMP-Dependent Protein Kinasescell typecultured cell linedesigndesigningdevelop therapyfunctional genomicsgene expression analysisgene expression assaygene modificationgenetic analysisgenetically modifiedgenome scalegenome wide screengenome-widegenomewideglucose controlglucose homeostasisglucose regulationiPSiPSCiPSCsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinsightintervention designintervention developmentmalignant skin tumormelanocytemolecular modelingmutantontogenyparalogparalogous genepathwayphotoprotectionphotoprotectivepigmentpigmentationspromoterpromotorprotein blottingreceptorreconstituted skinrecruitresponseskin photoagingskin solar agingsocial rolesun burnsun lightsun light inducedsunlight-inducedtherapy designtherapy developmenttooltranscription factortranscriptional profilingtreatment designtreatment developmentultra violet damageultraviolet damage
Description preview
Project Summary
MITF, particularly the melanocyte-restricted m-MITF isoform, is a key transcription factor that regulates
melanocyte differentiation, survival, and pigmentation. Its expression is dynamically regulated by the MC1R
receptor through the PKA signaling pathway. For decades, it was thought that CREB1 was the PKA-controlled
transcription…
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