grant
Noise Trauma-Induced Cortical PV Neuron Dysfunction
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 6 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025(TNF)-αAcoustic Perceptual DisorderAcuteAntibodiesApoptosisApoptosis PathwayAuditoryAuditory Comprehension DisorderAuditory CortexAuditory Perceptual DiseasesAuditory Perceptual DisordersAuditory Processing DisorderAuditory areaBehavioralBody TissuesBrain DiseasesBrain DisordersBrain TraumaCD 120a AntigenCD 120b AntigenCD120a AntigensCD120b AntigensCachectinCell BodyCell DeathCell Death ProcessCell DifferentiationCell Differentiation processCell ProtectionCell SurvivalCell ViabilityCell modelCellsCellular modelConnector NeuronCustomCytoprotectionDegenerative Neurologic DisordersDiseaseDisorderDysfunctionEncephalon DiseasesFluorescenceFrequenciesFunctional disorderFunctional impairmentGene ExpressionImpairmentIn Situ Nick-End LabelingInflammatoryIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracranial CNS DisordersIntracranial Central Nervous System DisordersLinkMacrophage-Derived TNFMeasuresMediatingMembraneMethodsMiceMice MammalsMonocyte-Derived TNFMurineMusNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuronal DysfunctionNeuronsNoiseOutputParvalbuminsPathologyPhenotypePhosphorylationPhysiopathologyProceduresProgrammed Cell DeathProtein PhosphorylationPsychoacoustical DisordersPyramidal neuronRIP3RIPK3RIPK3 geneReceptor-Interacting Protein 3Receptor-Interacting Serine/Threonine Protein Kinase 3Receptors, Tumor Necrosis Factor, Type IIRecoveryResearchResearch ResourcesResourcesRinging-Buzzing-TinnitusRodent ModelRoleSliceStaining methodStainsSynapsesSynapticTNFTNF ATNF AlphaTNF Receptor p55TNF geneTNF-R2TNF-RIITNF-sR55TNF-αTNF-α receptorTNFATNFARTNFBRTNFR p60TNFR p75TNFR, 55-kDTNFR, 60-kDTNFR-ITNFR1TNFR2TNFR55TNFR60TNFR80TNFRSF1ATNFRSF1A ReceptorTNFRSF1A geneTNFRSF1BTNFRSF1B ReceptorTNFRSF1B geneTNFalpha receptorTNFαTNFα receptorTUNELTestingTimeTinnitusTissuesTransfectionTraumaTraumatic Brain InjuryTumor Necrosis FactorTumor Necrosis Factor Beta ReceptorTumor Necrosis Factor Receptor 1Tumor Necrosis Factor Receptor 2Tumor Necrosis Factor Receptor 55Tumor Necrosis Factor Receptor 75Tumor Necrosis Factor Receptor Type 2Tumor Necrosis Factor-alphaViral Vectorauditory processingcellular differentiationcentral processing disordercustomscytokinecytoprotectivedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningexperimentexperimental researchexperimental studyexperimentshippocampal pyramidal neuronknock-downknockdownmembrane structurenecrocytosisnerve cell deathnerve cell lossneural dysfunctionneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneurological diseaseneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossnoise exposurenoise traumaoptogeneticspatch clamppathophysiologypreventpreventingpromoterpromotorshRNAshort hairpin RNAsmall hairpin RNAsocial rolesynapseterminal nick end labelingtraumatic brain damagetumor necrosis factor alpha receptortumor necrosis factor receptor 1Atumor necrosis factor receptor superfamily, member 1Btumor necrosis factor α receptor
Description preview
PROJECT SUMMARY
Noise trauma can lead to loss of parvalbumin-positive inhibitory interneurons in the auditory cortex, which is
associated with audiotory processing deficit and tinnitus in rodent models. The mechanisms underlying noise-
induced PV neuron loss are unknown. We propose to systematically characterize noise-induced PV neuron
deficits…
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