grant

NMR Core

Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 29 Jul 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AddressAffinityAutomobile DrivingBindingBiologyCell BodyCell Communication and SignalingCell FunctionCell LineageCell PhysiologyCell ProcessCell SignalingCell surfaceCellsCellular AssayCellular FunctionCellular PhysiologyCellular ProcessChemicalsClosure by LigationCognitive DiscriminationCollaborationsComplementComplement ProteinsComplexCryo-electron MicroscopyCryoelectron MicroscopyDevelopmentDiscriminationDiseaseDisorderE coliE. coliElectron CryomicroscopyEnsureEscherichia coliFundingHandHigh Throughput AssayHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHistocompatibilityHistocompatibility ComplexHistocompatibility ComplicesIntracellular Communication and SignalingIsotope LabelingLabelLigand BindingLigandsLigationMHC ReceptorMajor Histocompatibility ComplexMajor Histocompatibility Complex ReceptorMajor Histocompatibility ComplicesMammaliaMammalsMeasurementMeasuresMethodsMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMotionNatureNuclearOutcomePaintPeptidesProcessPropertyProteinsQuality ControlReceptor CellRelaxationResolutionScanningSignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionSourceSpectroscopySpectrum AnalysesSpectrum AnalysisStable Isotope LabelingStructureSubcellular ProcessSurfaceSystemT cell responseT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteTechniquesThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissue CompatibilityWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyadaptive immunitybiological signal transductioncell assaycomplementationconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydevelopmentaldrivingdynamic systemdynamical systemexperimentexperimental researchexperimental studyexperimentshandshigh throughput screeninginsightinterfacialmechanical forcemolecular dynamicsmutantnovelpeptide structureprotein purificationreceptor functionresolutionsscreeningscreeningssingle moleculethymocytethymus derived lymphocytetool
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ABSTRACT – CORE C
To protect mammals from a vast array of diseases, adaptive immunity relies on T cells that recognize protein-

derived peptides from foreign, mutant, or otherwise aberrant sources presented on the surfaces of compromised

cells. Central to this process is the αβT cell receptor (TCR), which uses mechanical force to distinguish among…

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NMR Core — DANA-FARBER CANCER INST | UNITED STATES | Jul 2020 | Dev Procure