grant

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model

Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AgeAgingBody TissuesCell BodyCellsChromosomal StabilityChromosome StabilitiesDNA DamageDNA Helicase, RecQ-Like, Type 1DNA HelicasesDNA InjuryDNA Unwinding ProteinsDNA unwinding enzymeDysfunctionEnvironmentExposure toFoundationsFunctional disorderGeneHomologGenome StabilityGenomic StabilityHomologHomologous GeneHomologueHumanIncrease lifespanKO miceKnock-out MiceKnockout MiceKnowledgeLaboratoriesLesionMammaliaMammalsMiceMice MammalsModelingModern ManMurineMusNull MouseOrganPathway interactionsPhenotypePhysiopathologyPrincipal InvestigatorRECQ Protein-LikeRECQLRECQL geneRECQL1ResearchRodent ModelRoleStressTissuesage associatedage correlatedage dependentage linkedage relatedage specificagesboost longevitydietarydietary manipulationdisease phenotypeelongating the lifespanenhance longevityexperienceextend life spanextend lifespanextend longevityfoster longevityhelicaseimprove lifespanimprove longevityin vivoinnovateinnovationinnovativelifespan extensionmolecular pathologymouse modelmurine modelmutantnovelpathophysiologypathwayprolong lifespanprolong longevitypromote lifespanpromote longevityreplication stressresponsesocial rolesupport longevity
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The molecular pathologies caused by RecQ helicase deficiency are particularly difficult to characterize because five human RecQ homologs with partially overlapping functions exist. RECQL1 is the most abundant of the human RecQ helicases and has critical roles in genomic stability. We will characterize a defined RECQ1 knockout mouse model subjected…

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NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model — NATIONAL IN | Dev Procure