grant
NG2/CSPG4 in Mandibular Endochondral Fracture Healing
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAlkaline PhosphataseAnimal ModelAnimal Models and Related StudiesBiological MarkersBiologyBody TissuesBone RegenerationBone callusBony CallusCSPG4CSPG4 geneCalcifiedCallusCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCellular injuryChondrocytesClinicalClinical TreatmentCollagen Type VICranial SuturesDataDecision MakingDegenerative ArthritisDegenerative polyarthritisDevelopmentERK 1ERK1ERK1 KinaseEpiphyseal PlateEpiphysial cartilageExhibitsExtracellular Signal-Regulated Kinase 1ExtremitiesFacial BonesFractureFracture HealingGoalsGrowth PlateHealing abnormalHealing delayedImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpaired healingImpairmentIn VitroIncidenceInferior Maxillary BoneInstitutionIntima CollagenIntracellular Communication and SignalingJaw JointJoint structure of suture of skullKO miceKnock-out MiceKnockout MiceKnowledgeLigandsLimb structureLimbsLinkMAP Kinase 3MAPK3MAPK3 Mitogen-Activated Protein KinaseMAPK3 geneMCSPGMEL-CSPGMSK16MandibleMandible FractureMandibular FracturesMandibular jointMechanicsMembraneMentorsMitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase 3 GeneMolecularNG2NeckNon-TrunkNull MouseOralOsteoarthritisOsteoarthrosisOsteoblastsOsteotomyOutcomeOutcome StudyP44ERK1PSTkinase p44mpkPainPainfulPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPeriosteumPeriosteumsPhysiologic OssificationPhysiological OssificationPostoperativePostoperative PeriodProgenitor CellsProteoglycanQOLQuality of lifeReceptor ProteinRegulationResearchResearch ResourcesResolutionResourcesRoleScienceScientistSignal TransductionSignal Transduction SystemsSignalingSkeletal systemTMJTemporomandibular JointTestingTimeTissuesTrainingTransgenic OrganismsTraumaType VI (Intima) CollagenWestern BlottingWestern ImmunoblottingWorkalkaline phosphomonoesterasebio-markersbiologic markerbiological signal transductionbiomarkerbonebone fracturebone fracture healingbone fracture repaircalcificationcareer developmentcartilage cellcell damagecell injurycell typecellular damagecellular differentiationclinical interventionclinical therapycollagen 6collagen Type 6collagen VIcondylar cartilagecraniofacialcraniofaciesdamage to cellsdegenerative joint diseasedesigndesigningdevelopmentalface bone structurefracture repairglycerophosphatasehealinghypertrophic arthritisimprovedin vivoinjury responseinjury to cellsintramembranous bone formationintramembranous ossificationknock-out animalknockout animallab assignmentlab experimentlaboratory activitylaboratory assignmentlaboratory exerciselaboratory experimentmandibularmechanicmechanicalmechanical loadmembrane structuremineralizationmodel of animalmouse modelmurine modelneuron glial antigen 2new drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnormal ossificationnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetossa facieiossificationosteoblast progenitorosteoblast stem cellosteochondralosteochondral tissueosteogenicosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor cellp44 MAPKpathwaypatient oriented outcomespre-clinicalpreclinicalprogenitor cell differentiationprogenitor differentiationprotein blottingreceptorregenerate boneresolutionsresponseresponse to injurysocial rolestem and progenitor differentiationstem cell differentiationstem cellstransgenictrial regimentrial treatment
Description preview
PROJECT SUMMARY/ABSTRACT
This application represents a training plan designed to provide mentoring, career development, and support to
the applicant as a clinician-scientist seeking to move research from the benchtop to the bedside in craniofacial
and oral sciences. The training plan encompasses laboratory experimentation and professional and…
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