grant
Next generation of AAV vector targeting adipose tissue
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AAV vectorAAV-based vectorACRP30 proteinAdipocytesAdipose CellAdipose tissueAffectAlbuminsAllelism TestAmino Acid SequenceBSCL2BSCL2 geneBasic ResearchBasic ScienceBiodistributionBody TissuesBrainBrain Nervous SystemC57BL/6 MouseCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCapsidCas nuclease technologyClinical TrialsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplementary DNAComplementation TestCoupledDNA ShufflingDNA TherapyDNA cassetteDNA mutationDataDiseaseDisorderDoseDrug or chemical Tissue DistributionEducational MainstreamingEncephalonEngineeringEnhancersExclusionEyeEyeballFat CellsFatsFatty TissueFatty acid glycerol estersFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene DeliveryGene ExpressionGene TransferGene Transfer ClinicalGenetic ChangeGenetic Complementation TestGenetic InterventionGenetic defectGenetic mutationGreen Fluorescent ProteinsHeartHepatotoxic effectHepatotoxicityHumanHuman CloningHybridsIP injectionImmuneImmunesIn vivo analysisIntestinalIntestinesIntraperitoneal InjectionsIntravenousKidneyKidney Urinary SystemLeannessLeftLeptinLipocytesLipodystrophyLiverLiver ToxicityLuciferase ImmunologicLuciferasesLungLung Respiratory SystemMainstreamingMature LipocyteMature fat cellMediatingMessenger RNAMetabolicMetabolic syndromeMiceMice MammalsMicroRNAsModelingModern ManMolecular BreedingMouse Homolog of GNG3LGMurineMusMuscleMuscle TissueMutationNamesOb Gene ProductOb ProteinObese Gene ProductObese MiceObese ProteinObesityOral AdministrationOral Drug AdministrationPancreasPancreaticPeripheralPlasmidsPoint MutationPopulationPrimary Protein StructureProgenitor CellsProteinsRecommendationReporter GenesResearchRiskRouteSafetySerotypingSkeletal MuscleSpleenSpleen Reticuloendothelial SystemStomachTechnologyTextTherapeuticThinnessThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissue DistributionTissuesToxic effectToxic effect on liver cellsToxicitiesTrans TestTranscriptTransgenesTropismVariantVariationViralViral GenomeViral VectorVisceral fatVoluntary Muscleachievement Mainstream Educationadeno-associated viral vectoradeno-associated virus vectoradipocyte complement-related protein 30-kDaadipocyte, C1q and collagen domain containing proteinadipocytokinesadipokinesadiponectinadiposeadiposityagedapM-1 proteinapM1 (adipose-specific) proteinbowelcDNAcomplementation analysiscomplementation approachcorpulencedesigndesigningdetermine efficacyefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy testingenhancer cassetteevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsexpression cassetteflow cytophotometrygastricgene cassettegene manipulationgene repair therapygene therapygene-based therapygenetic cassettegenetic manipulationgenetic therapygenetically manipulategenetically perturbgenome editinggenome mutationgenomic editinggenomic therapyhepatic body systemhepatic organ systemhepatic toxicityhepatoxicityimprovedin vivo evaluationin vivo testingintegration cassetteintraoral drug deliveryintraperitonealmRNAmiRNAmuscularnamenamednamingnext generationnon-human primatenonhuman primatenovelob/ob mousepromoterpromoter cassettepromotorprotein sequencerenalreporter cassetteresistance cassetteseipinselectable cassetteselection cassetteshRNAshort hairpin RNAsmall hairpin RNAstem cellsstop cassettetooltranscription cassettetranscriptional cassettetransduction efficiencytransgenetransgene cassettetransgene expressionvectorviral DNAviral genomicsvirus DNAvirus genomevirus genomicswhite adipose tissueyellow adipose tissue
Description preview
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.
Adeno-associated viral (AAV) vectors are mainstream delivery platforms in gene therapy because of its safety profile and promising results in clinical trials. AAV has been successfully used to deliver transgenes to…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click