grant
Next Generation Infectious Disease Diagnostics: Microfluidic-Free Gigapixel PCR with Self-Assembled Partitioning
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAirway infectionsAssayBacterial InfectionsBioassayBiological AssayCMVCNS infectionCapillary ElectrophoresisCapillary Electrophoresis FractionationCentral Nervous System Bacterial InfectionsCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderClinicClinicalCommunicable DiseasesComplexConcentration measurementCustomCytomegalovirusDetectionDiagnosisDiagnosticDideoxy Chain Termination DNA SequencingEgypt 101 virusEmulsionsEquipmentFDA approvedFamilyFlaviviridaeFlavivirus InfectionsGenerationsHCMVHCV diseaseHIVHealthHepatitis CHepatitis, Viral, Non-A, Non-B, Parenterally-TransmittedHepatitus CHospital InfectionsHospital acquired infectionHospitalsHuman Immunodeficiency VirusesHuman ResourcesIndividualInfectionInfectious DiseasesInfectious DisorderInvestmentsLAV-HTLV-IIILaboratoriesLengthLicensingLiquid substanceLymphadenopathy-Associated VirusManpowerManualsMeasurementMeasuresMeningitisMethodsMicrofluidicsMinorMolecularNatureNosocomial InfectionsNucleic AcidsNucleotidesOrganismPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPersonsPreparationProceduresProtocolProtocols documentationReactionReportingReproducibilityResolutionRespiratory InfectionsRespiratory Tract InfectionsRoboticsRunningSalivary Gland VirusesSamplingSanger SequencingSepsisShippingSightSourceSpecialistSymptomsTechniquesTechnologyTestingTimeTubeVariantVariationViral DiseasesVirus DiseasesVirus-HIVVisionWNVWest Nile virusWorkZIKVZika Virusaccurate diagnosisaccurate diagnosticsarmbacteria infectionbacterial diseaseclinical diagnosticscostcustomscytomegalovirus groupdigitaldisease diagnosticfluidgastrointestinal infectionhep ChepChepatitis non A non Bhuman genome sequencinginnovateinnovationinnovativeinstitutional infectioninstrumentliquidliving systemmedical diagnosticmultiplex assaymultiplex detectionnext generationnon A, non B hepatitisnon-A, non-B hepatitisnovelnucleic acid quantitationpathogenpatient oriented outcomespersonnelpreparationsratiometricresolutionsrespiratoryrespiratory virusresponse to therapyresponse to treatmentself assemblyskillstechnology implementationtechnology validationtherapeutic responsetherapy responsetreatment responsetreatment responsivenessviral hepatitis Cviral infectionvirus infectionvirus-induced diseasevisual functionzikavµfluidic
Description preview
ABSTRACT
Infections by different pathogens can manifest with similar symptoms, but appropriate treatment requires specific
and accurate diagnosis. Clinicians often turn to multiplexed assays testing for many organisms (e.g. BioFire).
While these approaches can test for 50-70 organisms, they do not provide concentration titers, which is
necessary…
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