grant
Next-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium Indicators
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 5 Feb 2024Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AddressAdoptionAffectAli-esteraseAnimal ModelAnimal Models and Related StudiesAnimalsAreaAssayB-esteraseBenchmarkingBest Practice AnalysisBioassayBiologicalBiological AssayBiologyBioluminescenceBody TissuesBrainBrain Nervous SystemBuffersCAP-hydrolyzing EnzymeCalciumCapsaicin-Hydrolyzing EnzymeCarboxyesteraseCarboxylate EsteraseCarboxylester LipaseCarboxylesterase BCarboxylesterasesCarboxylic Ester HydrolaseCarboxylic Ester HydrolasesCatalysisCategoriesCell BodyCell Communication and SignalingCell SignalingCellsConsumptionDerivationDerivation procedureDirected Molecular EvolutionDisease ProgressionDoseElementsEncephalonEnergy TransferEngineeringExhibitsFP593FamilyFirefly LuciferasesHydrogen OxideImageImaging DeviceImaging InstrumentImaging ToolIn VitroInjectionsInsectaInsectsInsects InvertebratesIntracellular Communication and SignalingIntracellular Second MessengerIslands of Langerhans TransplantationIslands of Pancreas TransplantationIslets of Langerhans GraftingIslets of Langerhans TransplantationIsocarboxazid amidaseKidneyKidney Urinary SystemLearningLightLiverLuciferase ImmunologicLuciferasesLungLung Respiratory SystemMacrogolsMiceMice MammalsMolecularMonitorMurineMusNaproxen EsteraseNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-specific CarboxylesteraseNon-specific EsteraseNonspecific EsteraseO elementO2 elementOpticsOutcomeOxygenPancreatic Islets TransplantationPenetrationPerformancePhotinus luciferin 4 monooxygenasePhotonsPhotoradiationPhysiologicPhysiologicalPolyethylene GlycolsPolyethylene OxidePolyethyleneoxidePolyoxyethylenesPositionPositioning AttributePro-MegaProcaine EsteraseProductionPromegaProteinsReagentRenilla LuciferasesReporterReproducibilityResearchSea Pansy LuciferasesSecond Messenger SystemsSecond MessengersSensorySignal TransductionSignal Transduction SystemsSignalingSolubilitySystemTissuesToxic effectToxicitiesViral DiseasesVirus DiseasesWateranaloganimal imagingaqueousautologous islet transplantationawakebenchmarkbiologicbiological signal transductionbioluminescence imagingbioluminescent imagingcalcium indicatorcarboxylesterasechemical stabilitycoelenterazinedesigndesigningdirected evolutiondrFP583ds red proteindsFP593experimentexperimental researchexperimental studyexperimentsfundamental researchhepatic body systemhepatic organ systemimagingimaging studyin vitro Assayin vivointerestislet auto transplantationislet beta cell transplantationislet cell transplantislet cell transplantationislet transplantationluciferinmarinemarine environmentmetermodel of animalmouse modelmurine modelmutantneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnon-invasive imagingnoninvasive imagingnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopticaloxidationpre-clinicalpreclinicalpreventpreventingpublic health relevancered fluorescent proteinredshiftrenalresponsesignal transduction second messengerssuccesstooltumor xenograftviral gene deliveryviral infectionvirus infectionvirus-induced diseasewater solubility
Description preview
Abstract:
In 2012, Promega introduced NanoLuc, an ATP-independent marine luciferase mutant exhibiting a high photon
production rate in the presence of a synthetic luciferin analog, furimazine. However, NanoLuc has several
unfavorable features, including low tissue penetration of its blue emission, and limited substrate solubility and
stability.…
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