grant
New tools from chemistry and antibodies to address receptor function
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAdenosineAffectAlpacaAngiotensin ReceptorAntibodiesAssayBindingBioassayBiologicalBiological AssayBiologyCamelsCell BodyCell Surface ProteinsCell Surface ReceptorsCellsCharacteristicsChemicalsChemistryDevelopmentDiabetes MellitusDiseaseDisorderExhibitsG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGLP-1 receptorGLP-I receptorGPCRGoalsImmune systemIn VitroInflammationLlamaMammalian CellMarriageMethodologyMethodsMolecular InteractionMuscarinic Acetylcholine ReceptorMuscarinic ReceptorsNK-1 ReceptorsNK1RNKIRNeurokinin-1 ReceptorsOrganic ChemistryOsteoporosisPTH-PTHrP ReceptorPTH-Related Peptide ReceptorPTH-Related Protein ReceptorPTH1 receptorPTHLP ReceptorPTHrP ReceptorParathyroid Hormone ReceptorParathyroid Hormone Receptor 1Parathyroid Hormone Receptor Type IParathyroid Hormone-Like Peptide ReceptorParathyroid Hormone-Related Peptide ReceptorPeptidesPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhysiologicPhysiologicalProcessPropertyProteinsReagentReceptor ProteinSP-P ReceptorsSpecificitySubstance P ReceptorSurfaceTAC1RTACR1TACR1 geneTachykinin Receptor 1TestingTherapeuticVHHVHH antibodyantibody conjugatebiologiccamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chainchronic paindesigndesigningdevelopmentaldiabetesglucagon-like peptide-1 receptorinterestnanobodiesnanobodynew approachesnon-natural amino acidsnon-proteinogenic amino acidsnonproteinogenic amino acidsnovel approachesnovel strategiesnovel strategypharmaceuticalpharmacologicprotein functionreceptorreceptor functionresponsesdAbsingle domain antibodiessmall moleculetooltranslational modelunnatural amino acidsvariable heavy chain antibody
Description preview
Cell surface receptors are a principal target of compounds used in therapeutic applications. One fundamental challenge of pharmaceutical development is identifying compounds that are highly specific for their target of interest, exhibit high potency and efficacy, and induce receptor responses with desirable characteristics. The broad goal of this…
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