grant

New methods for computational modeling of RNA structures

Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Apr 2020Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAnti-viral AgentsAreaBiologyBiomedical ResearchBiophysicsCOVID-19 virusCOVID19 virusCRISPRCRISPR/Cas systemClustered Regularly Interspaced Short Palindromic RepeatsCoV-2CoV2Computational toolkitComputer ModelsComputerized ModelsComputing MethodologiesDataDevelopmentFoundationsFutureGene TranscriptionGenetic TranscriptionGrantHybridsKineticsLearningLifeMachine LearningMedicineModelingMolecular ConfigurationMolecular ConformationMolecular StereochemistryNon-Polyadenylated RNAPositionPositioning AttributeRNARNA ConformationRNA ExpressionRNA FoldingRNA Gene ProductsRNA SequencesRNA targeting drugRNA targeting therapeuticsRNA vaccineRNA-based vaccineRNA-targeting therapyRibonucleic AcidSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Small RNAStructureTechniquesTechnologyTherapeuticTherapeutic Gene EditingThermodynamicThermodynamicsTranscriptionVaccine DesignWuhan coronavirusanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbiophysical approachesbiophysical equipmentbiophysical foundationbiophysical methodologybiophysical methodsbiophysical principlesbiophysical sciencesbiophysical techniquesbiophysical toolscomputational methodologycomputational methodscomputational modelingcomputational modelscomputational toolboxcomputational toolscomputational toolsetcomputer based methodcomputer based modelscomputer methodscomputerized modelingcomputerized toolscomputing methodconformationconformationalconformational stateconformationallyconformationscoronavirus disease 2019 viruscoronavirus disease-19 virusdesigndesigningdevelopmentaldisease preventiondisorder preventiongene-editing therapygenome editinggenome editing based therapygenome editing therapygenome editing treatmentgenome editing-based therapeuticsgenomic editinghCoV19mRNA vaccinemRNA-based vaccinemachine based learningnCoV2small moleculetherapeutic editingtherapeutic genome editingtool
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Project Summary
The past five years have ushered in a transformative era in biomedical research. With the development of life-

saving SARS-CoV-2 mRNA vaccines, FDA approval of the first RNA-targeted drug, and FDA approval of the first

CRISPR-based gene editing therapy, RNA is revolutionizing key areas of medicine. Despite these remarkable…

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New methods for computational modeling of RNA structures — UNIVERSITY OF MISSOURI-COLUMBIA | UNITED STATES | Apr 2020 | Dev Procure