grant
New mechanisms governing skin tissue residency memory T cells
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoVAdoptive Cell TransfersAffinityAntigenic DeterminantsAntigensApoptosisApoptosis PathwayAutoimmuneAutoimmune StatusAutoimmunityAutoregulationB7-H1Binding DeterminantsBiologyBody TissuesCD274CD8CD8BCD8B1CD8B1 geneCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 virusCOVID-19 yearsCOVID19 virusCancersCell BodyCell Communication and SignalingCell CycleCell DeathCell Division CycleCell SignalingCell TherapyCellsCellular ImmunologyChicken PoxChickenpoxChronicCoV-2CoV2DataDendritic CellsDetectionDevelopmentDiseaseDisease OutbreaksDisorderDrugsEngraftmentEnsureEpitopesEquilibriumEventFutureGeneticGoalsGrippeHealthHomeostasisIMiDImmuneImmune ToleranceImmune memoryImmune modulatory therapeuticImmunesImmunityImmunizationImmunologic MemoryImmunologic ToleranceImmunological MemoryImmunologyInfectionInflammationInfluenzaInjuryInterventionIntracellular Communication and SignalingKnowledgeLYT3LengthLength of LifeLife CycleLife Cycle StagesLigandsLongevityLungLung Respiratory SystemMHC ReceptorMaintenanceMajor Histocompatibility Complex ReceptorMalignant MelanomaMalignant NeoplasmsMalignant TumorMediatingMedicationMelanomaMemoryMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsModelingMolecularMonkey PoxMonkeypoxNeoplasm MetastasisOrganOutbreaksPD 1PD-1PD-1 antibody therapyPD-1 therapyPD-L1PD1PD1 antibody therapyPD1 based treatmentPDL-1PathogenicityPatientsPeptidesPeripheralPharmaceutical PreparationsPhasePhysiological HomeostasisPopulationPoxvirus officinalePre-Clinical ModelPreclinical ModelsProgrammed Cell DeathProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1ProliferatingProteinsPsoriasisReceptor ActivationReceptor SignalingRecurrenceRecurrentResidenciesRoleSARS VirusSARS corona virusSARS corona virus 2SARS coronavirusSARS-Associated CoronavirusSARS-CO-V2SARS-COVID-2SARS-CoVSARS-CoV-1SARS-CoV-2SARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-CoV2SARS-Related CoronavirusSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Secondary NeoplasmSecondary TumorSentinelSevere Acute Respiratory CoronavirusSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome related corona virus 2ShapesSignal TransductionSignal Transduction SystemsSignalingSiteSkinSkin TissueSmallpoxSmallpox VaccineStem Cell likeSurvey InstrumentSurveysSynapsesSynapticSystems BiologyT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT memory cellT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT-cell receptor repertoireT-cell therapeuticsT-cell transfer therapyTCR repertoireTeff cellTestingTherapeuticTissue ModelTissuesToxic effectToxicitiesTransgenic MiceTumor EscapeTumor Immune EscapeVaccine DesignVaccinesVaccinia virusVaricellaVariolaVeiled CellsViralVirusVitiligoWorkWuhan coronavirusaPD-1 therapyaPD-1 treatmentaPD1 therapyaPD1 treatmentadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyadoptive cell therapyadoptive cellular therapyanamnestic reactionanti-PD-1 therapyanti-PD-1 treatmentanti-PD1 therapyanti-PD1 treatmentanti-programmed cell death 1 therapyanti-programmed cell death protein 1 therapyantigen challengeautoimmune attackautoimmune destructionautoimmune pathogenesisautoinflammationbalancebalance functionbiological signal transductioncancer evasioncancer immune escapecancer immune evasioncancer metastasiscell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapycombatcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 viruscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 viruscutaneous tissuedevelopmentaldrug/agenteffector T cellexhaustionhCoV19immune check pointimmune checkpointimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulatory agentsimmune modulatory drugsimmune system toleranceimmune unresponsivenessimmune-mediated adverse eventsimmune-related adverse effectimmune-related adverse eventsimmune-related adverse reactionimmunecheckpointimmunization strategyimmunogenimmunological paralysisimmunomodulating agentsimmunomodulating drugsimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulatory agentsimmunomodulatory drugsimmunomodulatory therapeuticsimprovedin vivoin vivo Modelinjuriesinjury to tissueinsightlife courselife spanlifespanmalignancymemory T lymphocytememory recallmouse modelmpoxmurine modelnCoV2necrocytosisneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpharmacologicphysiologic modelpreservationpreventpreventingprogenitorprogenitor capacityprogenitor cell likeprogenitor-likeprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein 1 therapyprogrammed cell death protein ligand 1programmed death 1protein death-ligand 1psoriasiformpsoriaticpublic health relevancerecombinant vaccinia virusrecruitresident memory T cellsecondary immune responsesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome-CoVsle2small poxsmall pox vaccinesocial rolesoundstem cell characteristicsstem-likestemnesssynapsesystemic lupus erythematosus susceptibility 2telomeretherapeutic T-cell platformthymus derived lymphocytetissue injurytissue resident memory T celltooltumor cell metastasistumor evasiontumor immune evasionvaccination strategyvariola major
Description preview
PROJECT SUMMARY
Given the recent SARS CoV2 pandemic, and monkeypox outbreak, there is an urgent unmet need to understand
immunity in our barrier tissues (e.g. skin, lung, and gut) where viruses are encountered. Tissue specific memory
is needed for long-lived protective immunity, including immunization strategies that target infections and cancers…
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