grant
Neurovascular Interactions: Mechanisms, Imaging, Therapeutics
Organization J. DAVID GLADSTONE INSTITUTESLocation SAN FRANCISCO, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2033
NIHUS FederalResearch GrantFY20252-photon2-photon microscopy3-D3-Dimensional3DAnimal ModelAnimal Models and Related StudiesApoplexyBBB disruptionBBB permeabilizationBBB permeableBiologyBloodBlood ProteinsBlood Reticuloendothelial SystemBlood VesselsBrainBrain Nervous SystemBrain TraumaBrain Vascular AccidentCNS DiseasesCNS autoimmunityCNS disorderCOVID-19CV-19CausalityCell BodyCell Communication and SignalingCell SignalingCellsCellular biologyCentral Nervous System DiseasesCentral Nervous System DisordersCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCommunicationCoronavirus Infectious Disease 2019Degenerative Neurologic DisordersDevelopmentDiseaseDisorderDisseminated SclerosisElectron MicroscopyElectrophysiologyElectrophysiology (science)EncephalonEtiologyExperimental DesignsExtravasationFoundationsGeneticGenomicsGliaGlial CellsGoalsImageImaging DeviceImaging InstrumentImaging ToolImmuneImmune systemImmunesImmunologyIntracellular Communication and SignalingKolliker's reticulumLaboratoriesLeakageMediatingMediatorMethodsMolecularMultiple SclerosisNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyNeurosciencesNeurovascular dysfunctionNon-neuronal cellNonneuronal cellOutcomes ResearchPlasma ProteinsProteomicsResolutionRoleSignal TransductionSignal Transduction SystemsSignalingSpillageStrokeTherapeuticTraumatic Brain InjuryVascular Systembiological signal transductionblood-brain barrier disruptionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrier disruptionbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain attackcausationcell biologycentral nervous system autoimmunitycerebral vascular accidentcerebrovascular accidentcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19degenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldisease causationelectrophysiologicalglial activationglial cell activationimagingin vivoinnovateinnovationinnovativeinsular sclerosismodel of animalmultidisciplinarynerve cementneural degenerationneural inflammationneuro-vascularneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneurological diseaseneuron toxicityneuronalneuronal degenerationneuronal toxicityneurotoxicityneurovascularneurovascular abnormalityneurovascular dysregulationneurovascular impairmentneurovascular pathologyneurovasculopathynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyphospho-proteomicsphosphoproteomicsrepairrepairedresolutionssocial rolestrokedstrokessuper high resolutionsuperresolutionthree dimensionaltooltranscriptomicstraumatic brain damagetwo photon excitation microscopytwo photon microscopytwo-photonultra high resolutionvascular
Description preview
The neurovascular interface fundamentally changes during CNS diseases due to increased blood-brain barrier permeability and influx of plasma proteins in the CNS parenchyma. Studying neurologic diseases through the multidisciplinary prism of vascular biology, immunology, and neuroscience could be critical for the identification of novel mechanisms…
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