grant
Neurophysiology of Reward Signaling in Parkinson's Disease
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026Active Follow-upActive LearningAcuteAddressAttenuatedAwardBasal GangliaBasal NucleiBehaviorBehavioral SymptomsCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell Communication and SignalingCell SignalingChronicClinicalCognition DisordersCognitiveCognitive ManifestationsCognitive SymptomsCompulsive BehaviorComputational TechniqueCooperative LearningDWI (diffusion weighted imaging)DWI-MRIDataDecision MakingDeep Brain StimulationDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDopamineDrugsElectrodesEngineeringEnvironmentExperiential LearningFosteringFundingFutureGamblingGangliaGoalsHumanHydroxytyramineImplantImpulsive BehaviorInstitutionIntracellular Communication and SignalingInvestigatorsK-AwardsK-Series Research Career ProgramsKnowledgeLearningMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMental DepressionMental disordersMental health disordersMentorsMentorshipMethodsModern ManNMR ImagingNMR TomographyNational Institutes of HealthNerve Impulse TransmissionNerve TransmissionNeural GanglionNeurological SurgeryNeuronal TransmissionNeurosurgical ProceduresNuclear Magnetic Resonance ImagingNucleus SubthalamicusOperative ProceduresOperative Surgical ProceduresParalysis AgitansParkinsonParkinson DiseasePathologicPatientsPharmaceutical PreparationsPhysiciansPhysiologic pulsePhysiologyPlayPrefrontal CortexPrimary ParkinsonismProcessPsychiatric DiseasePsychiatric DisorderPulseResearchResearch Career ProgramResearch PersonnelResearch ResourcesResearchersResourcesRewardsRisk TakingSTN stimulationScientistSignal TransductionSignal Transduction SystemsSignalingStructure of subthalamic nucleusStudy SubjectSubthalamic NucleusSurgicalSurgical InterventionsSurgical ProcedureSymptomsTechniquesTrainingTransmissionUnited States National Institutes of HealthZeugmatographyactive followupassociated symptomattenuateattenuatesaxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncareercareer developmentco-morbid symptomco-occuring symptomcognitive diseasecognitive disordercognitive syndromecomorbid symptomconcurrent symptomcooccuring symptomdMRIdepressiondevelopmentaldiffusion tensor imagingdrug/agenteffective therapyeffective treatmentexperiencefollow upfollow-upfollowed upfollowupglia signalingglial signalingimprovedinstrumentmachine based learningmental illnessmood symptommotor symptomnerve signalingneural controlneural regulationneural signalingneural stimulationneuromodulationneuromodulatoryneuronal signalingneurophysiologicalneurophysiologyneuroregulationneurosurgeryneurotransmissionnon-motor symptomnonmotor symptomnovelpatient populationpsychiatric illnesspsychiatric symptompsychological disorderrecruitreward circuitryreward processingscreeningscreeningsskillssubthalamic nucleus stimulationsurgerysymptom associationsymptom comorbiditysymptom treatmentsymptomatic treatmenttransmission processtreat symptom
Description preview
PROJECT SUMMARY
Altered reward signaling plays a key role in multiple Parkinson’s disease nonmotor symptoms including
depression, apathy, and impulsive and compulsive behaviors. Moreover, therapies for Parkinson’s disease
including dopaminergic medication and deep brain stimulation have been associated with both pathologic
increases and decreases…
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