grant
Neuronal regulation of tissue-resident macrophage maintenance and polarization
Organization KANSAS STATE UNIVERSITYLocation MANHATTAN, UNITED STATESPosted 1 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AddressAfferent NeuronsAlveolar MacrophagesAutoregulationBody TissuesBody cavitiesCalcitonin Gene-Related PeptideCell Communication and SignalingCell SignalingComplexDataDevelopmentDiseaseDisorderDysfunctionEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentExhibitsFunctional disorderGreater sac of peritoneumHomeostasisImmunomodulationInfectionInflammationInflammatoryInjuryInnate Immune ResponseIntracellular Communication and SignalingKnowledgeLifeLigandsLungLung Respiratory SystemMacrophageMaintenanceMediatingMiceMice MammalsModalityModelingMurineMusMφNerveNerve CellsNerve FibersNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeuropeptide ReceptorNeuropeptidesNociceptionNociceptorsPainPainfulPathogenesisPeripheralPeritoneal CavityPeritoneal MacrophagesPhysiological HomeostasisPhysiopathologyPulmonary MacrophagesReceptor ProteinReceptor SignalingRegulationResearchRoleSensory NeuronsSepsisSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStimulusSystemTherapeuticTissuesbiological signal transductionbody cavitydevelopmentalgain of functionimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedin vivoinjuriesinnervationloss of functionnerve supplyneuronalnociceptivenociceptive neuronspain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspathophysiologyprogramsreceptorrepairrepairedsocial roletissue repair
Description preview
PROJECT SUMMARY
The barrier tissues and body cavities are densely innervated by nociceptor sensory neurons (or nociceptors) that
respond to noxious stimuli and mediate pain. Nociceptive innervation in the lung and peritoneal cavity begins as
early as the embryonic development stage. Similarly, long-lived tissue-resident macrophages (TRMs), such as…
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