grant
Neuromuscular response to competing ACL surgeries
Organization RHODE ISLAND HOSPITALLocation PROVIDENCE, UNITED STATESPosted 30 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ACL injuryACL reconstructionACL repairACL ruptureACL tearAbscissionActive Follow-upAddressAgeAnatomic SitesAnatomic structuresAnatomyAncillary StudyAnimalsAnteriorAnterior Cruciate LigamentAthleticBasic ResearchBasic ScienceBinomial DistributionBlood ClottingBlood coagulationCNS Nervous SystemCartilageCartilaginous TissueCell-Extracellular MatrixCentral Nervous SystemClassificationClinical ResearchClinical StudyClinical TrialsCommunicationCommunitiesControl GroupsConventional SurgeryCoupledCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataDecision MakingDisease Frequency SurveysDysfunctionECMElectromyographyElementsEnrollmentExcisionExtirpationExtracellular MatrixFunctional disorderFutureHealthHospitalsImplantIndividualInferiorInjuryJoint HypermobilityJoint LaxityJointsKneeLegLengthLigamentsLinear ModelsLongitudinal StudiesLower ExtremityLower LimbMachine LearningMeasurementMechanicsMechanoreceptorsMembrum inferiusMotionMuscleMuscle TissueMuscle functionNeuraxisOperative ProceduresOperative Surgical ProceduresOutcomeParentsParticipantPatient Outcomes AssessmentsPatient ParticipationPatient Reported MeasuresPatient Reported OutcomesPatientsPatternPhasePhysiopathologyPositionPositioning AttributeProceduresRandomized, Controlled TrialsReconstructive Surgical ProceduresRecoveryRegression AnalysesRegression AnalysisRegression DiagnosticsRemovalResearchResearch DesignRhode IslandRiskRisk FactorsSample SizeSignal PathwaySiteStatistical RegressionStructureStudy TypeSurfaceSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSystematicsTechniquesTestingTimeTraumatic ArthritisTraumatic ArthropathyVisitactive followupadult youthagesanterior cruciate ligament injuryanterior cruciate ligament reconstructionanterior cruciate ligament repairanterior cruciate ligament ruptureanterior cruciate ligament tearboneclinical relevanceclinically relevantdamage to ligamentdemographicsenrollfollow upfollow-upfollowed upfollowupfunctional outcomeshamstringhealinghigh riskimaging studyinjuriesinnovateinnovationinnovativejoint functionkinematic modelkinematicsligament damageligament injuryligamentous injurylong-term studylongitudinal outcome studiesmachine based learningmachine learning based classificationmachine learning classificationmechanicmechanicalmuscle strengthmuscularneuralneuromuscularneuromuscular activityneuromuscular functionnovelparentparticipant enrollmentpathophysiologypatient enrollmentpost-traumatic osteoarthritispre-clinicalpreclinicalpreservationrandomized control trialrandomized, clinical trialsreconstruction surgeryreconstructive surgeryrecruitresectionresponserestorationscaffoldscaffoldingsexstandard of carestudy designsupport vector machinesurgerytendon grafttibiatrial comparingvectoryoung adultyoung adult ageyoung adulthood
Description preview
ABSTRACT
The overall project objective is to leverage patients enrolled in the BEAR-MOON Trial to evaluate a
neuromuscular mechanism that may explain differences in functional outcomes between the novel
bridge-enhanced anterior cruciate ligament restoration (BEAR) and the standard of care, anterior
cruciate ligament reconstruction surgery (ACLR).…
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