grant
Neuromuscular changes in the aging larynx
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 15 Aug 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AD dementiaAbscissionAcousticsAction PotentialsAcuteAddressAffectAge MonthsAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal Experimental UseAnimal ExperimentationAnimal ModelAnimal Models and Related StudiesAnimal ResearchAnimalsAppearanceAssayAtrophicAtrophyBioassayBiologicalBiological AssayBiology of AgingBiometricsBiometryBiostatisticsCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell Communication and SignalingCell SignalingCellular biologyCommon Rat StrainsCommunicationCommunication challengeCommunication difficultyDataDeglutitionDevelopmentDiagnosisDimensionsDoctor of PhilosophyE-stimEfferent NeuronsElderlyElectric StimulationElectrophysiologyElectrophysiology (science)EvaluationExcisionExtirpationFacultyFoundationsGoalsHistologyHumanImpairmentIndividualInjuryIntracellular Communication and SignalingInvestigationInvestigatorsK-AwardsK-Series Research Career ProgramsKnowledgeLaryngealLaryngeal InjuryLaryngeal MusclesLaryngeal TraumaLaryngeal muscle structureLaryngectomyLarynxLarynx Head and NeckLeannessLongitudinal StudiesMeasuresMental DepressionMentorsMethodsMitochondriaModelingModern ManMotorMuscleMuscle AtrophyMuscle FibersMuscle MitochondriaMuscle TissueMuscle functionMuscular AtrophyMyoneural JunctionMyotubesNerveNeuromuscular DiseasesNeuromuscular JunctionNeurophysiology / ElectrophysiologyNeurosciencesOperative ProceduresOperative Surgical ProceduresOutcome MeasurePh.D.PhDPhysiciansPopulationPostdocPostdoctoral FellowPresbyacusisPresbycusisPrimary Senile Degenerative DementiaProductionProgram DevelopmentQOLQuality of lifeRatRats MammalsRattusRecoveryRecurrent Laryngeal NerveRemovalResearchResearch AssociateResearch Career ProgramResearch PersonnelResearchersRhabdomyocyteSarcosomesScientistSignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSocial isolationSurgeonSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSwallowingTechniquesTestingThinnessTimeTrainingTraining ProgramsTranslationsVisualVocal FoldVoiceadvanced ageadvanced age ratsage associatedage associated alterationsage associated changesage associated hearing lossage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage induced alterationsage induced changesage induced hearing lossage linkedage relatedage related alterationsage related changesage related decline in hearingage related hearing deficitsage related hearing impairmentage related hearing lossage specificage specific alterationsage specific changesaged groupaged groupsaged individualaged individualsaged muscleaged peopleaged personaged personsaged populationaged populationsaged rataged ratsaging associated alterationsaging associated changesaging associated hearing lossaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging induced hearing lossaging of muscleaging populationaging related alterationsaging related changesaging related decline in hearingaging related hearing deficitsaging related hearing impairmentaging related hearing lossaging specific alterationsaging specific changesalterations with ageanimal experimentationsbiologicbiological signal transductioncareer developmentcell biologychanges with ageclinical predictorsclinical significanceclinically significantcohortdensitydepressiondevelopmentaleffective therapyeffective treatmentefferent nerveelderly ratselectrophysiologicalelectrostimulationexperiencegeriatricgeriatric ratshuman subjectin vivoinjuriesinjury recoveryinnervationlarynx musclelong-term studylongitudinal outcome studiesmeasurable outcomemechanical forcemitochondrialmodel of animalmuscle agingmuscle breakdownmuscle degradationmuscle deteriorationmuscle lossmuscle physiologymuscle wastingmuscularmyoneural disordernerve supplyneuromuscularneuromuscular degenerative disorderneuromuscular disorderneurophysiologicalneurophysiologyold ratsoutcome measurementpopulation agingpost-docpost-doctoralpost-doctoral traineeprimary degenerative dementiaprimary outcomeprogramsrecovery after injuryrecovery following injuryrecovery post injuryrecruitresearch associatesresectionresponsesenile dementia of the Alzheimer typesenior citizenstandard measuresurgerytranslationvocal cordvocalizationvoice box
Description preview
Project Summary
Age-related vocal atrophy (ARVA) affects a substantial portion of the population. ARVA impairs voice,
swallowing, and communication, and is associated with social isolation, depression, and reduced quality of life.
Vocal fold muscles are thin, bowed, with an incomplete closure during voicing. The underlying reason individuals…
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