grant
Neuroimaging and Connectome Analysis as a Diagnostic and Prognostic Biomarker of SCI Induced Neuropathic Pain
Organization THOMAS JEFFERSON UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 26 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025Acute PainAcutely painfulAffectiveAnalgesia TestsAnteriorAreaAssessment instrumentAssessment toolBiological MarkersBrainBrain Nervous SystemBrain regionCare GiversCaregiversCerebrumChronicClinicalClinical TreatmentClinical TrialsComplexDWI (diffusion weighted imaging)DWI-MRIDeep Brain StimulationDevelopmentDiagnosisDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDorsal Root GangliaDrug TherapyEncephalonEsthesiaFunctional MRIFunctional Magnetic Resonance ImagingFutureGoalsGraphHumanHyperalgesiaHyperalgesic SensationsImageIndividualIndividual DifferencesInjuryInterruptionInterventionLifeLiteratureMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaintenanceMath ModelsMeasuresMedialMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedical RehabilitationMedulla SpinalisMethodsModern ManModificationMultimodal ImagingNMR ImagingNMR TomographyNerve CellsNerve UnitNetwork AnalysisNetwork-basedNeural CellNeurobiologyNeurocyteNeuronsNeurostimulation procedures of spinal cord tissueNociception TestsNodalNuclear Magnetic Resonance ImagingNumeric Rating ScaleNumerical ScaleOpiatesOpioidOutcomePETPET ScanPET imagingPETSCANPETTPainPain AssessmentPain ControlPain MeasurementPain TherapyPain managementPain measurePainfulParticipantPathway AnalysisPathway interactionsPatient RecruitmentsPatient Self-ReportPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatternPersonsPharmacological TreatmentPharmacotherapyPhenotypePopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredicting RiskPrefrontal CortexProcessPrognostic MarkerProtocolProtocols documentationPublic HealthRad.-PETRehabilitationRehabilitation therapyResearchRestSCI PatientsSelection CriteriaSelf-ReportSensationSensorySensory DisordersSomatosensory CortexSpinal CordSpinal Cord StimulationSpinal Cord TraumaSpinal GangliaSpinal TraumaSpinal cord injuredSpinal cord injurySpinal cord injury patientsSpinothalamic TractsStructureTechniquesTestingThalamic structureThalamusTranslational ResearchTranslational ScienceTraumatic MyelopathyTreatment outcomeVeteransWorkZeugmatographyallodyniabio-markersbiologic markerbiomarkerbrain basedcandidate selectioncerebralchronic neuropathic painchronic paincingulate cortexclinical efficacyclinical interventionclinical painclinical therapyconnectomedMRIdevelopmentaldiagnostic biomarkerdiagnostic markerdiffusion tensor imagingdorsal root gangliondrug interventiondrug treatmentdynamic systemdynamical systemeffective therapyeffective treatmentendophenotypeexperiencefMRIforecasting riskgraph theoryhyperalgiaimagingimprovedinjuriesmathematic modelmathematical modelmathematical modelingmilitary membermulti-modal imagingmulti-modal neuro-imagingmulti-modalitymulti-modality imagingmultimodal neuroimagingmultimodalitymultimodality imagingneuralneural controlneural imagingneural net architectureneural network architectureneural regulationneuro-imagingneurobiologicalneurochemicalneurochemistryneuroimagingneuroimaging biomarkerneuroimaging markerneurological imagingneuromodulationneuromodulatoryneuronalneuropathic painneuroregulationnon-invasive diagnosisnon-invasive diagnosticnoninvasive diagnosisnoninvasive diagnosticpain assaypain interventionpain processingpain reductionpain treatmentpainful neuropathyparticipant recruitmentpathwaypatient oriented outcomespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost interventionpre-clinical studypreclinical studypredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskprognostic biomarkerprognostic indicatorpsychologicpsychologicalpsychosocialreduce painrehab therapyrehabilitativerehabilitative therapyrisk predictionrisk predictionssensory cortexservice memberside effectsomesthetic sensory cortexspinal cord injury painspinothalamic pathwaystatisticsthalamictooltranslation researchtranslational investigationtrial regimentrial treatment
Description preview
The identification of prognostic and diagnostic biomarkers of spinal cord injury (SCI) and SCI induced pain will
help to assign SCI patients to the correct treatment and rehabilitation regimes. Chronic neuropathic pain (NP) is
a complicated condition after a SCI that often has a lifelong and significant negative impact on life after the injury;…
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