grant
Neurodevelopmental Mechanisms Underlying the Onset of Depression Amount At-Risk Youth: The Role of Dysregulation in the Negative Valence System
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 May 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20250-11 years oldAddressAffectAgeAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAreaBehaviorBehavioralBrainBrain Nervous SystemCentral LobeChildChild YouthChildren (0-21)DataDepressed moodDevelopmentDiagnosisDifferences between sexesDiffers between sexesDysfunctionEarly DiagnosisEarly identificationEconomic BurdenEmotionalEmotional DepressionEmotionsEncephalonEvent-Related PotentialsExhibitsFemaleFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGeneral PopulationGeneral PublicGoalsGroups at riskHigh Risk WomanHistoryImageImpoverishedIndividualInsulaInsula of ReilInterventionIntervention StudiesInterviewInvestigatorsIsland of ReilK23 AwardK23 MechanismK23 ProgramKnowledgeLinkLongitudinal StudiesMajor Depressive DisorderMeasuresMental DepressionMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)ModelingMothersNIMHNational Institute of Mental HealthNegative ValenceOnset of illnessPathway interactionsPatient Self-ReportPeople at riskPerformancePersons at riskPhonePhysiologicPhysiologic PsychologyPhysiologicalPhysiological PsychologyPhysiopathologyPopulations at RiskPovertyPreventionPrincipal InvestigatorPropertyPsychophysiologicalPsychophysiologyPubertyRecording of previous eventsRecurrenceRecurrentRegulationResearch PersonnelResearchersRestRiskRisk MarkerRoleSample SizeSamplingSelf-ReportSeriesSex DifferencesSexual differencesSpecificityStimulusStrategic PlanningSurvey InstrumentSurveysSymptomsSystemTelephoneTestingTimeWorkYouthYouth 10-21adolescent depressionadolescents with depressionaffective neuroscienceagesamygdaloid nuclear complexat-risk femalesat-risk womenbiological sexbiomarker discoverybrain basedchild depressionchildhood depressionchildhood onset depressionclinical applicabilityclinical applicationclinical depressioncognitive controlcost effectivedepresseddepressed adolescentsdepressed motherdepressiondepression in adolescencedepression preventiondepression symptomdepressivedepressive symptomsdevelopmentaldisease onsetdisease preventiondisease riskdisorder onsetdisorder preventiondisorder riskearly adulthoodearly detectionemerging adultemotional stimulusevent related potentialfMRIfemales at high riskhigh riskhigh risk femaleshistoriesimagingimaging studyimprovedindexinginnovateinnovationinnovativeintervention researchinterventional researchinterventional studyinterventions researchkidslong-term studylongitudinal outcome studiesmajor depressionmajor depression disordermaternal depressionmulti-modalitymultimodalitynetwork dysfunctionnoveloffspringpathophysiologypathwaypediatric depressionphysiopsychologypsycho-physiologicalrecruitresponserisk predictorrisk predictorssadnesssexsex based differencessex-dependent differencessex-related differencessex-specific differencessocialsocial rolestatisticssupport networktheorieswomen at high riskyoungsteryouth ageyouth depression♀
Description preview
PROJECT SUMMARY
Offspring of mothers with major depressive disorder (MDD) are at substantially elevated risk for developing
depression by early adulthood. Devastatingly, 60% of these high risk (HR) youth will meet criteria for MDD by
age 25, versus only 16% of individuals in the general population. Recognized by the 2022 NIMH Strategic Plan,
the…
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