grant
Neurocognitive Outcomes and the Trajectory of Recovery One-year After Pediatric Sepsis
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20250-11 years oldAcetylcholine AgentsActive Follow-upAcuteAddressAgeAnti-CholinergicsAnticholinergic AgentsAnticholinergicsBehaviorBiologicalBiometricsBiometryBiostatistical MethodsBiostatisticsCare GiversCaregiversCaringCessation of lifeChildChild YouthChildhoodChildren (0-21)Children with DisabilitiesChildren's HospitalCholinergic AgentsCholinergic DrugsClinical ResearchClinical StudyCognitiveCritical IllnessCritically IllCritically ill childrenDataDeathDeliriumDevelopmentDisabled ChildrenDrugsDysfunctionEducationEducational aspectsElectronic Health RecordEmploymentEquipment and supply inventoriesEvaluationExposure toFunctional disorderFutureGlasgow Coma ScaleGoalsGrafting ProcedureHandicapped ChildrenHospitalsHourInstitutionInventoryJointsKnowledgeLearningLong-term prospective studiesMapsMeasurementMeasuresMedicationMentorshipMethodsModelingMorbidityMorbidity - disease rateNeurocognitiveNeuropsychologiesNeuropsychologyOrgan TransplantationOrgan TransplantsOutcomeOutcome MeasurePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPediatric HospitalsPennsylvaniaPerformancePersonsPharmaceutical PreparationsPhiladelphiaPhysiopathologyPrevalenceRecoveryRegistriesReportingResearchResearch InfrastructureResearch ResourcesResourcesRisk FactorsSchool-Age PopulationScientistScoring MethodSecondary toSepsisSolidSurvivorsTestingTrainingUnited StatesUniversitiesValidationabnormal brain functionactive followupadvanced analyticsafter sepsisafter septicagedagesanalytical methodantisepsis treatmentbiologicbrain dysfunctionbrain impairmentcareer developmentchildren with sepsischolinergic neuroncognitive functioncohortcritically ill childdeath riskdeliriousdevelopmentaldrug/agentdysfunctional brainelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordexecutive controlexecutive functionexperiencefollow upfollow-upfollowed upfollowing sepsisfollowing septicfollowuphealth related quality of lifehigh riskimprovedimproved outcomekidslongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designlongitudinal, prospective studymalleable riskmeasurable outcomemodifiable riskmortalitymortality riskmultidisciplinaryneurocognitive testneuropsychologicorgan allograftorgan graftorgan xenograftoutcome measurementpathophysiologypatient oriented outcomespediatricpediatric sepsispediatric septicpost sepsispost septicpreventpreventingprogramspsychosocialresponseschool agesecondary outcomesepsis caresepsis in childrensepsis interventionssepsis managementsepsis survivorsepsis survivorshipsepsis therapeuticssepsis therapysepsis treatmentseptic childrenseptic survivalseptic survivorseptic therapyseptic treatmentsurvive sepsissurvivorshipsystemic inflammationsystemic inflammatory responsetime usetreat sepsistreatment strategyvalidationsyoungster
Description preview
PROJECT SUMMARY
Acute brain dysfunction (ABD) during sepsis occurs in 30% of children and is associated with a seven-fold
increased risk of mortality. Survivors who experienced ABD during sepsis are more likely to have both
functional morbidity and a reduction in health-related quality of life. However, there is a critical knowledge gap
about the…
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