grant
Neural Stem Cell Aging and Neurodegeneration
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Mar 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AD dementiaAD patientsAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease patientAlzheimer's patientAlzheimers DementiaAmentiaAmmon HornAttenuatedAutoregulationBiochemicalBioenergeticsBiogenesisBiologyBody TissuesC elegansC. elegansC.elegansCaenorhabditis elegansCell BodyCell DeathCellsChaperoneChromatinChronic DiseaseChronic IllnessCognitionCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalCornu AmmonisDataDefectDegenerative DisorderDementiaDentate FasciaDeteriorationDevelopmentDiseaseDisorderDisturbance in cognitionDysfunctionFascia DentataFunctional disorderGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGenomic approachGrowthGyrus DentatusGyrus HippocampiGyrus ParahippocampalisHDAC4HDAC4 geneHDACAHippocampal GyrusHippocampusHistone Deacetylase 4Histone Deacetylase AHomeostasisImpaired cognitionIncrease lifespanIntermediary MetabolismInterventionKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLinkMammaliaMammalsMetabolic ProcessesMetabolismMitochondriaMitochondrial ProteinsMolecular ChaperonesNerve DegenerationNeural Stem CellNeuron DegenerationNull MouseNutrientOrigin of LifeOxidative StressParahippocampal GyrusPathway interactionsPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPredispositionPrimary Senile Degenerative DementiaProgenitor CellsProliferatingProteinsRNA ExpressionRepressionRisk FactorsRoleSignal PathwayStressSusceptibilityTestingTissue GrowthTissuesTranscriptionTranslationsUpregulationaged miceaged mouseagesaging associated diseaseaging associated disordersaging related diseaseaging related disordersattenuateattenuatesboost longevitychronic disordercognitive dysfunctioncognitive lossdegenerative conditiondegenerative diseasedentate gyrusdevelopmentaldisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdrug developmentelderly miceelongating the lifespanenhance healthspanenhance longevityexperienceextend healthspanextend life spanextend lifespanextend longevityextending healthy lifespanfeasibility testingfoster longevitygain of functiongenetic approachgenetic strategygenomic effortgenomic strategyhealthspanhealthspan extensionhealthy life spanhippocampalimprove healthspanimprove lifespanimprove longevityimprovedincrease healthspanknock-downknockdownlife spanlifespanlifespan extensionmitochondrialmodel organismmouse modelmurine modelnatural agingnecrocytosisnerve stem cellneural controlneural degenerationneural precursorneural precursor cellneural progenitorneural progenitor cellsneural regulationneural stem and progenitor cellsneurodegenerationneurodegenerativeneurogenesisneurogenic progenitorsneurogenic stem cellneurological degenerationneuromodulationneuromodulatoryneuron progenitorsneuronal degenerationneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorneuroregulationnormal agingnormative agingnovelold ageold miceontogenyoverexpressoverexpressionoxidative damageoxidative injurypathophysiologypathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADprematureprematurityprimary degenerative dementiaprogenitor agingprogenitor and neural stem cellsprogenitor cell agingprogenitor cell maintenanceprogenitor maintenanceprogramsproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialprolong healthspanprolong lifespanprolong longevitypromote healthspanpromote lifespanpromote longevityprotein foldingprotein homeostasisproteostasisresponsescRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem cell agingstem cell maintenancestem cellssupport longevitytissue degenerationtranslation
Description preview
Project Summary
Perturbation of mitochondrial proteostasis, a form of mitochondrial stress, activates the mitochondrial unfolded
protein response (UPRmt), a retrograde signaling pathway leading to transcriptional up-regulation of
mitochondrial chaperones and stress relief. Recent advances in mitochondrial biology link UPRmt to lifespan
extension…
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