grant
Neural mechanisms of psilocybin action in the frontal cortex
NIHUS FederalResearch GrantFY20252-photon5-HT Receptors5-HT(2C) Receptor5-HT2C Receptor5-Hydroxytryptamine Receptors5-Hydroxytryptamine Type 2C ReceptorsAffectAlcohol dependenceAreaArea Under CurveAttentionBrainBrain Nervous SystemCalciumCell BodyCellsClinical TrialsCognitionCognitiveConnector NeuronCouplingCre driverCyclic SomatostatinDataDendritesEncephalonExperimental DesignsFrequenciesGeneticGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHallucinogenic AgentsHallucinogenic DrugsHallucinogenic SubstancesHallucinogensImageIn vivo two-photon calcium imagingIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronKO miceKnock-out MiceKnockout MiceLabelLinkMedialMediatingMediatorMiceMice MammalsMoodsMurineMusNeocortexNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsNull MouseOpiate AddictionOpiate DependenceOutputPHM27PatternPerceptionPopulationPsilocibinPsilocybinPsychedelic AgentsPsychedelicsPsychotomimetic AgentsPyramidal neuronReceptor ProteinRoleSRIHSRIH-14Serotonin 2C ReceptorSerotonin Receptor 5-HT2CShapesSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSubstance Use DisorderTherapeutic EffectVasoactive Intestinal PeptideVasoactive Intestinal PolypeptideVasointestinal Peptideaddictionaddiction to psychostimulantsaddiction to stimulantsaddictive disorderalcohol addictionalcohol dependencyalcohol dependentexecutive controlexecutive functionexperienceexperimentexperimental researchexperimental studyexperimentsfrontal cortexfrontal lobegrowth hormone release inhibiting factorhippocampal pyramidal neuronhomotypical corteximagingimprovedin vivo calcium imaginginformation processinginsightisocortexneopalliumneural cell bodyneural circuitneural circuitryneural mechanismneurobiologicalneurocircuitryneuromechanismneuronalneuronal cell bodyneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatryneurotrophic factorneurotrophinneutrophinopioid addictionopioid dependenceopioid dependentpsychedelic drugpsychostimulant addictionpsychostimulant dependencepsychotomimetic drugreceptorrecruitresponseserotonin receptorsingle cell analysissocial rolesomastimulant addictionstimulant dependencesubstance use and disordersubstance use treatmentsynaptic circuitsynaptic circuitrytooltranscriptomicstwo-photon
Description preview
PROJECT SUMMARY
Serotonergic psychedelics are best known for altering perception, cognition, and mood. Recently, there has been
a resurgence in clinical trials investigating psychedelics for their potential in treating neuropsychiatric illnesses,
such as substance use disorder. Psilocybin-assisted therapy, for example, holds promise in treating…
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