grant
Neural Mechanisms of Motivated Movement
Organization CARNEGIE-MELLON UNIVERSITYLocation PITTSBURGH, UNITED STATESPosted 15 Apr 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AffectAnimal ModelAnimal Models and Related StudiesAnimalsApoplexyAreaBasketballBehaviorBehavior ControlBehavioralBehavioral ManipulationBehavioral ModelBehavioral ParadigmBeliefBiologic ModelsBiological ModelsBleedingBrainBrain Nervous SystemBrain Vascular AccidentCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeChokingClinicalCognitiveCoupledDA NeuronData SetDeathDimensionsDiseaseDisorderDopamineDopamine AntagonistsDopamine Receptor AntagonistsDopamine neuronDopaminergic AntagonistsDorsalElectromyographyEncephalonExhibitsFrustrationGoalsHandHemorrhageHumanHydroxytyramineIncentivesInfusionInfusion proceduresIntracellular Communication and SignalingLearningLinkM mulattaM. mulattaMacaca mulattaMacaca rhesusManufactured basketballMediatingMedical RehabilitationMesencephalonMid-brainMidbrainMidbrain structureModel SystemModelingModern ManMonkeysMotivationMotorMotor CortexMovementMuscleMuscle TissueNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNoiseOutcomeOutputParalysis AgitansParkinsonParkinson DiseasePathway interactionsPatternPerformancePersonsPhasePlayPopulationPrimary ParkinsonismProcessPsychologic TheoryPsychological TheoryRehabilitationRehabilitation therapyResearchRewardsRhesus MacaqueRhesus MonkeyRoleShapesSignal TransductionSignal Transduction SystemsSignalingStrokeStructureSubconsciousSystemTestingTimeUncertaintyWorkaddictionaddictive disorderarmarm movementaxon signalingaxon-glial signalingaxonal signalingbehavior influencebehavioral controlbehavioral influencebiological signal transductionblood lossbody movementbrain attackbrain computer interfacecerebral vascular accidentcerebrovascular accidentdensitydesigndesigningdopamine systemdopaminergic neurondoubtdriving behaviorexperienceexperimentexperimental researchexperimental studyexperimentsfascinateglia signalingglial signalinghandshigh rewardimprovedinfusionskinematic modelkinematicsmodel of animalmotivated behaviormotor controlmotor rehabmotor rehabilitationmotor rehabilitative therapymuscularnerve signalingneuralneural circuitneural circuitryneural controlneural mechanismneural regulationneural signalingneurocircuitryneuromechanismneuromodulationneuromodulatoryneuronalneuronal signalingneurophysiologicalneurophysiologyneuroregulationneurotransmissionpathwaypressurerehab therapyrehabilitativerehabilitative therapyresponsereward anticipationreward processingskillssocial rolestrokedstrokessynaptic circuitsynaptic circuitry
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Project Summary
Movements are influenced by motivation. Consider a basketball player shooting a free-throw. Depending on the
stakes of the outcome of the shot, performance can vary greatly. Top athletes rise to the challenge, and perform
better during a game than they do during practice. But when the stakes are inordinately high, like when the…
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