grant
Neural Mechanisms Linking Sensory Perception and Social Behavior
NIHUS FederalResearch GrantFY20252-photon21+ years oldASDAcuteAddressAdultAdult HumanAutismAutistic DisorderBehaviorBehavioralBrainBrain Nervous SystemCell Communication and SignalingCell SignalingClinicalCognitive DiscriminationColorConnector NeuronCuesCyclic SomatostatinDataDevelopmentDiscriminationDown-RegulationDysfunctionEarly Infantile AutismEarly InterventionEarly identificationElectrophysiologyElectrophysiology (science)EncephalonFore-BrainForebrainFunctional disorderGene AlterationGene MutationGeneralized GrowthGeneticGoalsGrowthGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHeadImageImaging ProceduresImaging TechnicsImaging TechniquesImpairmentInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingKanner's SyndromeKnowledgeLifeLinkMeasuresMechanicsMembrane PotentialsMental disordersMental health disordersMiceMice MammalsMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptidesNeurophysiology / ElectrophysiologyOcytocinOutcomeOxytocinOxytocin ReceptorPatternPerceptionPhysiopathologyProcessProsencephalonPsychiatric DiseasePsychiatric DisorderPyramidal CellsReceptor SignalingRecombinant OxytocinReportingResearchRestResting PotentialsRisk FactorsRoleSRIHSRIH-14Secondary toSensorySensory DeprivationSignal TransductionSignal Transduction SystemsSignalingSocial BehaviorSocial FunctioningSocial InteractionSomatosensory CortexSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneStructureSymptomsSynapsesSynapticSynaptic plasticityTactileTestingTextureTimeTissue GrowthTransmembrane PotentialsVibrissaeWhiskersWorkadulthoodautism spectral disorderautism spectrum disorderautistic individualsautistic peopleautistic spectrum disorderbehavior outcomebehavioral impairmentbehavioral outcomebiological signal transductioncell typeclinical relevanceclinically relevantco-morbidco-morbiditycomorbiditydevelopmentaldiagnostic biomarkerdiagnostic markerelectrophysiologicalexperiencefunction sociallyfunctioning socialgene defectgenetic approachgenetic strategygrowth hormone release inhibiting factorimagingimpaired behaviorin vivoindividuals on the autism spectrumindividuals on the spectrumindividuals with ASDindividuals with autismindividuals with autism spectrum disorderinformation processinginsightmechanicmechanicalmental illnessmouse modelmurine modelmutant alleleneural correlateneural mechanismneurobiological mechanismneuromechanismneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypathophysiologypeople on the autism spectrumpeople with ASDpeople with autismpeople with autism spectrum disorderpreferencepsychiatric illnesspsychological disordersensory cortexsocialsocial cognitionsocial communicationsocial contactsocial defectssocial deficitssocial disorderssocial dysfunctionsocial rolesociobehaviorsociobehavioralsomesthetic sensory cortexsynapsetranslational impacttwo-photon
Description preview
PROJECT SUMMARY
Abnormalities in sensory perception are prevalent features in individuals with autism spectrum disorders
(ASD), accompanying the core social deficits. A central challenge in autism research is to identify alterations in
neurobiological mechanisms that underlie processes as distinct as sensory perception and social cognition. As…
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