grant
Neural and Renal Contributions to Hypertension with Androgen Deprivation Therapy
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AccountingAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAdverse effectsAffectAgonistAmerican maleAmerican manAmerican menAndrogen ReceptorAndrogen SuppressionAndrogenic AgentsAndrogenic CompoundsAndrogensB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBP controlBP homeostasisBP managementBP regulationBSF-2BSF2Baroreceptor ReflexBaroreflexBiological MarkersBlood PressureBrain StemBrainstemCancer SurvivorCancer SurvivorshipCancersCardiac ChronotropismCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular PhysiologyCardiovascular systemCause of DeathCessation of lifeCirculationClinicalColoradoCommon Rat StrainsDataDeathDevelopment PlansDiagnosisDistalDoctor of PhilosophyDysfunctionEffectivenessEndocrine Gland SecretionEnvironmentExerciseFSH-Releasing HormoneFunctional disorderFundingFutureGeneralized GrowthGlomerular Filtration RateGoalsGonadal Steroid HormonesGonadoliberinGonadorelinumGonadotropin Hormone Releasing HormoneGonadotropin-Releasing HormoneGrowthHPGFHeart RateHeart VascularHepatocyte-Stimulating FactorHistoryHormonesHumanHybridoma Growth FactorHypertensionIFN-Gamma-Inducing Factor GeneIFN-beta 2IFN-gamma-Inducing FactorIFNB2IGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-18IL-18 GeneIL-1gIL-1g GeneIL-6IL18IL18 ProteinIL18 geneIL1F4IL1F4 GeneIL6 ProteinImpaired Renal FunctionImpairmentIndividualInflammationInflammatoryInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-6InvestigatorsIsometric ExerciseIsometricsKidneyKidney DiseasesKidney Urinary SystemLCN2LCN2 geneLH-FSH Releasing HormoneLH-Releasing HormoneLHFSH Releasing HormoneLipocalin 2LiverLongitudinal StudiesLuliberinLuteinizing Hormone-Releasing FactorMGC12320MGC12320 GeneMGI-2Malignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMeasuresMedicalMedical OncologistMentorsMentorshipMetastatic Prostate CancerMicroinjectionsModern ManMuscle-Setting ExerciseMyeloid Differentiation-Inducing ProteinNGALNephropathyNerveNeuronal DysfunctionNeurophysiology - biologic functionNeutrophil Gelatinase-Associated LipocalinObservation researchObservation studyObservational StudyObservational researchOncogenic Lipocalin 24P3OutcomePatientsPh.D.PhDPhysiologyPhysiopathologyPlacebo ControlPlacebosPlasmacytoma Growth FactorPopulationPre-Clinical ModelPreclinical ModelsProstate CAProstate CA therapyProstate CancerProstate Cancer therapyProstate Carcinoma MetastaticProstate malignancyProteomicsPulstiRandomized Controlled Clinical TrialsRatRats MammalsRattusReceptor InhibitionRecombinant GonadorelinRecording of previous eventsReflexReflex actionRenal Blood FlowRenal DiseaseRenal Plasma FlowRenal VascularRenal functionRenal vesselsResearchResearch DesignResearch PersonnelResearchersResistanceRiskRodentRodentiaRodents MammalsRoleScientific Advances and AccomplishmentsSecureSex HormonesSex Steroid HormonesSham TreatmentStatic ExerciseStudy TypeSurvival RateSystemTechnical ExpertiseTestingTestosteroneTherapeutic AndrogenTherapeutic GRHTherapeutic HormoneTherapeutic TestosteroneTimeTissue GrowthTrainingTrans-TestosteroneTranslatingTubularTubular formationU.S. MalesUS MenUS maleUniversitiesUterocalinVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular resistanceWorkacute kidney injuryandrogen ablation therapyandrogen blockade therapyandrogen deprivation therapyandrogen deprivation treatmentarmaspiratebio-markersbiologic markerbiomarkerblood pressure controlblood pressure elevationblood pressure homeostasisblood pressure managementblood pressure regulationblood pressure variabilitycardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular functioncardiovascular healthcardiovascular riskcardiovascular risk factorcareer developmentcirculatory systemcytokinedeclines in circulating testosteronedeclining testosteronedecreased levels of testosteronedecreases in testosteronedecreasing testosteronedeficiency in testosteronediminished testosteroneelevated blood pressureexperiencefatty acid-binding proteinsfollicle stimulating hormone-releasing factorgonadal steroidsgonadotropin releasing factorhepatic body systemhepatic organ systemhigh blood pressurehistorieshyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedincrease in blood pressureincreased blood pressureinhibitorinsightinterferon beta 2kidney disorderkidney dysfunctionkidney functionkidney injury molecule 1kidney vascularkidney vascular structurelong-term studylongitudinal outcome studieslow circulating testosteronelow levels of testosteronelower testosteronemales in Americamales in the U.S.males in the USmales in the USAmales in the United Statesmalignancymalleable riskmeetingmeetingsmenmen in Americamen in the U.S.men in the USmen in the USAmen in the United Statesmid lifemid-lifemiddle agemiddle agedmidlifemodifiable riskmortalitymultidisciplinaryneoplasm/cancerneuralneural circuitneural circuitryneural controlneural dysfunctionneural functionneural regulationneurocircuitryneuromodulationneuromodulatoryneuroregulationolder menontogenypathophysiologyplacebo controlledprofessorprostate cancer survivorsprostate cancer treatmentprostate survivorsrandomized control clinical trialrat KIM-1 proteinrecruitreduced testosteronereduction in testosteroneregulate BPregulate blood pressurerenalrenal KIM-1renal disorderrenal dysfunctionrenovascularresistantresponsescientific accomplishmentsscientific advancessex steroidsham therapyside effectskillssocial rolestudy designsynaptic circuitsynaptic circuitrytechnical skillstestosterone declinetestosterone deficiencytestosterone insufficiencytestosterone lossvascular constrictionvasoconstriction
Description preview
PROJECT SUMMARY / ABSTRACT
CANDIDATE: Matthew C. Babcock, Ph.D. is an Assistant Professor at the University of Colorado Anschutz
Medical Campus (CU-AMC). Dr. Babcock aims to study the neural and renal contributions to hypertension with
androgen deprivation therapy (ADT). He has developed preliminary data indicating that 1) men with lower…
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