grant
Neural and Cognitive Mechanisms Underlying Perseverance and Their Disruption After Juvenile Social Play Deprivation
Organization UNIV OF MARYLAND, COLLEGE PARKLocation COLLEGE PARK, UNITED STATESPosted 19 Apr 2026Deadline 18 Apr 2029
NIHUS FederalResearch GrantFY20260-11 years old12-20 years old21+ years old3-D print3-D printer3D Print3D printer3D printingAddressAdolescenceAdolescentAdolescent YouthAdultAdult HumanAdverse ExperienceAdverse effectsAdverse eventAgeAnimalsAnteriorAreaBackBehaviorBehavioralBrainBrain Nervous SystemChildChild YouthChildren (0-21)CognitionCognitiveCognitive deficitsCommon Rat StrainsComplexComputer ModelsComputerized ModelsCuesCuriositiesCustomDecision MakingDevelopmentDiffusionDihydrohydroxycodeinoneDivorceDivorced stateDorsumDrugsEconomicsElectrodesElectrophysiologyElectrophysiology (science)EmotionalEncephalonEquilibriumEvolutionFactor AnalysesFactor AnalysisFacultyFailureFrustrationGleanGoalsHome environmentIncubatedInvestigatorsLaboratoriesLearningLifeLinkLiteratureMediatingMedicationModelingNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocognitionNeurocognitiveNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyOutcomeOxycodeinonOxycodoneOxycodone SROxycontinPerforationPerformancePharmaceutical PreparationsPhasePlayPredispositionProcessPsychological reinforcementRatRats MammalsRattusReinforcementRelapseResearch PersonnelResearch ResourcesResearchersResourcesRewardsRiskRisk FactorsRodentRodent ModelRodentiaRodents MammalsRoleRoxicodoneRunningShapesSocial BehaviorSocial EnvironmentSocial InteractionStressSubstance Use DisorderSusceptibilitySynapsesSynapticTestingTherapeutic InterventionTrainingVisual CortexWorkaddictionaddictive disorderadolescence (12-20)adulthoodagesaxon signalingaxon-glial signalingaxonal signalingbalancebalance functioncareerchild neglectchildhood neglectcingulate cortexcognitive controlcognitive defectscognitive performancecognitive taskcomputational modelingcomputational modelscomputer based modelscomputerized modelingcravingcritical periodcustomsdeprivationdesigndesigningdevelopmentaldiffuseddiffusesdiffusingdiffusionsdrug seeking behaviordrug/agentearly adversityearly childhood adversityearly life adversityeconomicelectrophysiologicalexecutive controlexecutive functionexperienceexperimentexperimental researchexperimental studyexperimentsfallsflexibilityflexibleglia signalingglial signalingin vivoinnovateinnovationinnovativeinsightinterpersonal competenceinterpersonal competencyintervention therapyjuvenilejuvenile humankidslater in lifelater lifemulti-modalitymultimodalitynerve signalingneuralneural circuitneural circuitryneural mechanismneural signalingneurocircuitryneuromechanismneuronalneuronal signalingneuropsychiatric diseaseneuropsychiatric disorderneurotransmissionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoutcome predictionoxycodone self-administrationpeerperiadolescentpsychologicpsychologicalresilienceresilientresponseself-administer oxycodoneskillssocialsocial climatesocial competencesocial competencysocial contactsocial contextsocial defectssocial deficitssocial disorderssocial dysfunctionsocial relationshipssocial rolesocial skillssociobehaviorsociobehavioralsocioenvironmentsocioenvironmentalsubstance use and disordersynapsesynaptic circuitsynaptic circuitrysynaptic pruningthree dimensional printingtraining opportunityvisual corticalyoungster
Description preview
PROJECT SUMMARY / ABSTRACT
Early life adversity (ELA) is associated with a greater risk for later life substance use disorder and cognitive
deficits. In contrast, positive social relationships can preclude the enduring effects of ELA. Isolation rearing in
rodent models causes social deficits in adulthood, but the impact on executive functioning…
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