grant
Neural and behavioral mechanisms of obesity development from infancy through childhood
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Apr 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years old6-11 years oldAccelerationAddressAdultAdult HumanAgeAppetiteAppetitive BehaviorBehaviorBehavioralBehavioral MechanismsBody WeightBrainBrain Nervous SystemCNS Nervous SystemCentral Nervous SystemChildChild YouthChildhoodChildren (0-21)Corpus StriatumCorpus striatum structureDataData AnalysesData AnalysisData SetDesire for foodDevelopmentDiet HabitsDietary FactorsDietary HabitsEarly InterventionEatingEating BehaviorEncephalonEnvironmental FactorEnvironmental Risk FactorFamily StudyFoodFood IntakeFoundationsFunctional MRIFunctional Magnetic Resonance ImagingFundingGene variantGeneticGenetic predisposing factorGliosisGoalsHealthHomeHypothalamic structureHypothalamusIndividualInflammatory ResponseIntakeInterventionLeadLifeMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMechanisms of Behavior and Behavior ChangeMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMethodsNMR ImagingNMR TomographyNational Institutes of HealthNervous System FindingNeuraxisNeurologic FindingNeurological observationsNuclear Magnetic Resonance ImagingObesityOutcomeParentsParticipantPathogenesisPatternPb elementPerformanceReportingResearchRewardsRisk FactorsRoleStriate BodyStriatumStructureTestingTimeUnited States National Institutes of HealthVariantVariationWeightWeights and MeasuresZeugmatographyadiposityadulthoodagesallelic variantbehavior mechanismchild adipositychild obesitychildhood adipositychildhood obesitycognitive controlcohortcorpulencecue reactivitydata interpretationdevelopmentaldiscountingearly childhoodeating habitenvironmental riskexcessive weight gainextreme weight gainfMRIfeedingfood environmentgenetic risk factorgenetic variantgenomic variantgray matterheavy metal Pbheavy metal leadhomeshypothalamicindividual heterogeneityindividual variabilityindividual variationinfancyinfantileinherited factorinter-individual variabilityinter-individual variationkidslater in lifelater lifemiddle childhoodmyelinationneural mechanismneurobehavioralneuromechanismobese childrenobesigenicobesity developmentobesity during childhoodobesity in childrenobesity preventionobesity riskobesogenicparentpediatricpediatric obesitypostnatalpre-clinical researchpreclinical researchprenatalprepregnancy obesitypreventprevent obesitypreventingprotective factorsreward processingrisk for obesityrisk of obesityserious weight gainsevere weight gainsocial rolestriatalsubstantia griseaunbornweightsyoungster
Description preview
PROJECT SUMMARY
Obesity risk shows individual variation such that some children are more likely than others to gain excess
weight. One potential reason is that, due to genetic and environmental factors, individuals vary in appetitive
behaviors that drive food intake and weight. However, the neurodevelopmental mechanisms underpinning
variation in…
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