grant
Neural and Behavioral Consequences of Chronic THC Exposure During Adolescence
NIHUS FederalResearch GrantFY202512-20 years old21+ years oldActiqAddressAdolescenceAdolescentAdolescent YouthAdultAdult HumanAffective DisordersAnatomic SitesAnatomic structuresAnatomyAppetiteAreaAssociation LearningAssociative LearningAwarenessBOLD imagingBOLD responseBehaviorBehavioralBrainBrain Nervous SystemBrain regionCannabinoidsCannabisChronicCirculatory CollapseCocaineCognitionCognitiveCognitive DiscriminationCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalConditioned StimulusCorpus StriatumCorpus striatum structureCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataDesire for foodDevelopmentDiscriminationDisease Frequency SurveysDisturbance in cognitionDoseDrugsDuragesicEconomicsEncephalonEvaluationEventExposure toExtinctionFemaleFentanestFentanylFentylFoodFunctional MRIFunctional Magnetic Resonance ImagingHealthHistoryHumanIQ DeficitIllicit DrugsImmediate MemoryImpaired cognitionImpairmentInvestigationKnowledgeLaboratory StudyLearningLong-Term EffectsLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationModern ManMonkeysMood DisordersMotivationNMR ImagingNMR TomographyNeurocognitive DeficitNuclear Magnetic Resonance ImagingPavlovian conditioningPharmaceutical PreparationsPhentanylPriceProcessPropertyProtocolProtocols documentationPsychological reinforcementRecording of previous eventsReinforcementResearchRestRewardsRiskSaimiriSaimirusScanningSelf AdministeredSelf AdministrationShockShort-Term MemorySquirrel MonkeyStimulusStriate BodyStriatumStructureTHC co-useTHC exposureTHC useTailTestingTetrahydrocannabinol co-useTetrahydrocannabinol useTrainingWorkZeugmatographyabuse liabilityabuse potentialadolescence (12-20)adulthoodage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage induced alterationsage induced changesage related alterationsage related changesage specific alterationsage specific changesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageassociative conditioningaversive conditioningawakebehavior testbehavioral testblood oxygenation level dependent imagingblood oxygenation level dependent responsebrain circuitrycannabis usechanges with agecirculatory shockclassical conditioningco-morbidco-morbiditycognitive dysfunctioncognitive functioncognitive losscognitive processcomorbidityconditioningdevelopmentaldrug/agenteconomicexperimentexperimental researchexperimental studyexperimentsfMRIflexibilityflexiblehistorieshuman subjectintelligence quotient deficitinterestjuvenilejuvenile humanlater in lifelater lifelong-term studylongitudinal outcome studiesmalemarijuana usemotivated behaviormotivational processesmultidrug usemultiple drug useneuralneural correlateneural imagingneural patterningneuro-imagingneurocognitive declineneurocognitive impairmentneuroimagingneurological imagingnon-human primatenonhuman primatepoly drug usepolydrug usepricingprogramsprospectivereinforcerresponsereward processingshocksstriataltetrahydrocannabinol exposurevisual stimulusworking memory♀♂
Description preview
Abstract
Studies in humans suggest that frequent cannabis use during adolescence can alter brain structure and function
and impair motivational and cognitive processes. However, the extent to which such neural changes and
neurocognitive deficits persist into adulthood remains poorly understood, hampering the assessment of long-
term health risks.…
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