grant
Network models to capture multiple outcomes resulting from multi-component, salutogenic interventions
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 4 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20252'-deoxy-8-hydroxyguanosine8-OH-dG8-hydroxy-2'-deoxyguanosine8-hydroxydeoxyguanosine8-oxodGuoAffectAgeAge associated cognitive deficitAge associated cognitive dysfunctionAge related memory declineAge related memory deficitAge related memory impairmentAge-associated cognitive declineAge-related cognitive declineAgingAmmon HornAnimalsAttenuatedBehavioralBenign senescent forgetfulnessBiochemicalBloodBlood Reticuloendothelial SystemBody SystemBody TissuesBotanicalsC-reactive proteinCentella asiaticaCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplementary HealthComputer ModelsComputerized ModelsControl GroupsCornu AmmonisDataDevelopmentDiseaseDisease ProgressionDisorderDisturbance in cognitionExerciseFemaleFutureGenesGoalsGotu kolaGraphHealthHealth Care ResearchHealth PromotionHealth StatusHippocampusHumanHydrocotyle asiaticaHydrogen OxideImpaired cognitionIndividualInflammationInflammatoryIntegrative MedicineInterventionLaboratoriesLearningLevel of HealthMandukaparniMeasurementMeasuresMediatingMemoryMethodologyMethodsMiceMice MammalsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMurineMusMusculoskeletalOrganOrgan SystemOrganismOutcomeOxidative StressPathogenesisPathway interactionsPersonal SatisfactionProcessProteins, specific or class, C-reactiveRandomizedResearchRunningSalutogenesisSystemSystems BiologyTestingTherapeutic InterventionTissuesTrainingWaterWhole Organismage associatedage associated cognitive impairmentage associated memory declineage associated memory deficitage correlatedage dependentage linkedage relatedage related cognitive deficitage related cognitive dysfunctionage related cognitive impairmentage related memory dysfunctionage reversalage specificage-associated memory impairmentage-induced cognitive declineage-related decline in cognitionage-related decline in cognitive functionagedaged animalaged animalsaged miceaged mouseagesaging related cognitive declineaging reversalalleviate age relatedalleviate agingameliorating aginganimal old ageanimal tissueattenuateattenuatesbuild resiliencebuild resiliencycareercognitive changecognitive dysfunctioncognitive enhancementcognitive functioncognitive losscognitive taskcomputational modelingcomputational modelscomputer based modelscomputerized modelingcounter age relatedcounter agingcounteract age relatedcounteract agingdeep learning based modeldeep learning modeldesigndesigningdevelop resiliencedevelop resiliencydevelopmentaldrinking waterdynamic systemdynamical systemelderly animalelderly miceenhance resilienceenhance resiliencyexperienceexperimentexperimental researchexperimental studyexperimentsfacilitate resilienceglobal healthhealth datahealth levelhippocampalimprove resilienceimprove resiliencyimprovedincrease resilienceincrease resiliencyinsightintegrative healingintegrative healthinterestintervention therapyliving systemmalemetabolism measurementmetabolomicsmetabonomicsmodel buildingmodel generalizabilitymodel organismmolecular domainmolecular profilemolecular signaturemorris water mazemorris watermazemouse modelmurine modelnetwork modelsold animalsold micepathwayprogramspromote resiliencepromote resiliencypromoting healthrandomisationrandomizationrandomly assignedresilience developmentresponserestorationreverse agereverse agingreverse aging effectsreversible agingsextranscriptomicswell-beingwellbeingwhole healthwhole person healthyounger age♀♂
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Project Summary
Health care research has extensively studied disease pathogenesis, but very little is known about the
complementary process of health restoration, or salutogenesis. Salutogenesis may involve the use of single or
multiple interventions. These may affect multiple targets to restore specific functions as well as affect whole
person…
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