grant

Neocortical-hippocampal coordination and plasticity in sleep-dependent memory storage

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 4 Mar 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years oldAddressAdultAdult HumanAffectAmmon HornAnimalsArray tomographyBrainBrain Nervous SystemBrain regionCell BodyCellsCirculatory CollapseCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsCommunicationCornu AmmonisDNA RecombinationDataDentate FasciaDevelopmentDisturbance in cognitionDorsalEncephalonEntorhinal AreaExcitatory SynapseFascia DentataFast-Wave SleepFearFrightGene TranscriptionGeneticGenetic RecombinationGenetic TranscriptionGyrus DentatusHippocampusHourImpaired cognitionIndividualInterventionLaboratoriesLateralLearningLife ExperienceLinkMeasuresMedialMediatingMemoryMental HealthMental HygieneMiceMice MammalsMolecularMurineMusNREMNeocortexNerve CellsNerve DegenerationNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuron DegenerationNeuronsNeurosciencesParadoxical SleepPatternPopulationProcessProteinsPsychological HealthREM SleepRNA ExpressionRecombinationRhombencephalic SleepRoleSensoryShockSleepSleep DeprivationStructureSynapsesSynapticTestingTrainingTranscriptionUniversitiesVisualizationWorkadulthoodbehavior measurementbehavioral measurebehavioral measurementcell typecirculatory shockcognitive dysfunctioncognitive lossconditioned feardeficient sleepdensitydentate gyrusdevelopmentaldreaming sleepentorhinal cortexfear conditioningfear memoryfootgranule cellhippocampalhomotypical corteximprovedinadequate sleepinsightinsufficient sleepisocortexmemory consolidationmemory encodingmemory processmemory processingmemory trace reactivationnano meter scalenano meter sizednanometer scalenanometer sizednanoscaleneocorticalneopalliumneural degenerationneurodegenerationneurodegenerativeneurological degenerationneurological diseaseneuronalneuronal degenerationnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementoptogeneticspostsynapticpresynapticpreventpreventingrapid eye movement sleepshockssleep controlsleep debtsleep deficiencysleep deficitsleep insufficiencysleep losssleep regulationsleep/wake regulationsocial rolesynapsetooltranscriptomics
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Project summary: Turning fleeting life experiences into long-lasting memories is a fundamental function of the
brain and critical for survival. Across animal species, this process, which is linked to plastic changes at synapses

between neurons, has been shown to require transition into a sleeping brain state. However, very little is known

about 1)…

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Neocortical-hippocampal coordination and plasticity in sleep-dependent memory storage — UNIVERSITY OF MICHIGAN AT ANN AR | Dev Procure