grant
Neighborhood conditions, neural circuits, and substance use behaviors across the early life course.
Organization SUNY DOWNSTATE MEDICAL CENTERLocation BROOKLYN, UNITED STATESPosted 30 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202512-20 years oldAdolescenceAdolescent DevelopmentAdolescent and Young AdultAdult ChildrenAdult DaughtersAdult OffspringAdult SonsAffectAgeAlcohol Chemical ClassAlcoholsAreaBehaviorBlackBlack raceBrainBrain Nervous SystemCNS plasticityCannabisCausalityCharacteristicsChronic stressClinicalClinical TreatmentCocaineCocaine use disorderCognitiveCommunicationComplexDSM-5DSM-VDSM5DataData SourcesDevelopmentDiagnostic and Statistical Manual of Mental Disorders, 5th editionDiagnostic and Statistical Manual of Mental Disorders-VDifferences between sexesDiffers between sexesDiseaseDisease remissionDisorderDropsDrugsEEGEconomic ConditionsEconomic IncomeEconomical ConditionsEconomical IncomeEconomicsEducationEducational aspectsElectroencephalogramElectroencephalographyEmploymentEncephalonEnvironmental PollutantsEthnic OriginEthnicityEtiologyEventExposure toFamilyFemaleFrequenciesGWA studyGWASGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic RiskGenetic SusceptibilityGenetic propensityGenomicsGoalsHealthHispanicHistoryHouseholdIncomeIndividualInherited PredispositionInherited SusceptibilityLife CycleLife Cycle StagesLife ExpectancyLinkLiteratureLong-term prospective studiesLongitudinal StudiesMeasuresMedicationMethodsNatureNeighborhoodsNeural DevelopmentNeuronal PlasticityNicotineNicotine Use DisorderNon-HispanicNonhispanicNot Hispanic or LatinoOpiatesOpioidOutcomeParticipantPathway interactionsPharmaceutical PreparationsPlayProspective StudiesPublic HealthRaceRacesRecording of previous eventsRecurrenceRecurrentRemissionResearchRestRiskRisk FactorsRoleSamplingScientistSex DifferencesSexual differencesSocial ConditionsSocial EnvironmentSocietal ConditionsSocio-economic statusSocioeconomic StatusSubstance Use DisorderTobaccoUnited StatesVariantVariationWorkabnormal brain functionadolescence (12-20)adult youthagesalcohol outlet densityalcohol use disorderalcohol-related deathbrain dysfunctionbrain impairmentcannabis legalizationcannabis use disordercausationcentral nervous system plasticityclinical interventionclinical therapyco-morbidco-morbiditycognitive processcognitive taskcommunity level disadvantagecomorbiditydata archivedata archivesdata integrationdevelopmentaldisadvantaged communitydisease causationdisease riskdisorder riskdrug/agentdysfunctional brainearly adulthoodearly adversityearly childhood adversityearly experienceearly life adversityeconomicemerging adultenvironmental contaminantethanol use disordergenetic etiologygenetic mechanism of diseasegenetic risk for alcoholismgenetic vulnerabilitygenetic vulnerability to alcoholismgenetically predisposedgenetics of alcoholismgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic datagenomic datasetgenomic variationhigh riskhistoriesimprovedincomeslegal marijuanalegalized cannabislegalized marijuanalife courselife spanlifespanlong-term studylongitudinal outcome studieslongitudinal, prospective studylow SESlow socio-economic positionlow socio-economic statuslow socioeconomic positionlow socioeconomic statusmarijuana legalizationmarijuana use and disordermarijuana use disorderneighborhood barrierneighborhood disadvantageneighborhood-level barrierneighborhood-level disadvantageneuralneural circuitneural circuitryneural networkneural plasticityneurocircuitryneurodevelopmentneuroplasticneuroplasticityopiate crisisopiate use disorderopioid crisisopioid epidemicopioid use disorderpathwaypolygenic predictorspolygenic scoresracialracial backgroundracial originresidenceresidential buildingresidential segregationresidential siteresponsesex based differencessex risksex-dependent differencessex-related differencessex-specific differencessocialsocial climatesocial contextsocial rolesocio-demographic groupssocio-demographicssocio-economicsocio-economic adversitysocio-economic positionsocio-economicallysociodemographic groupsociodemographicssocioeconomic adversitysocioeconomic positionsocioeconomicallysocioeconomicssocioenvironmentsocioenvironmentalsubstance misusesubstance usesubstance use and disordersubstance usingsynaptic circuitsynaptic circuitrytraittrial regimentrial treatmentwhole genome association analysiswhole genome association studyyoung adultyoung adult ageyoung adulthood♀
Description preview
The etiology of substance use disorders (SUD, i.e., alcohol, cannabis, cocaine, opioids) are multifactorial, with risk factors including adverse social conditions, clinical comorbidities, neurodevelopmental influences, and genetic liabilities. However, little research has integrated data across these domains to study pathways of SUD risk. Given…
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