grant

Necessity of RNA degradosome assembly in Sinorhizobium meliloti for effective symbiosis

Organization SAN FRANCISCO STATE UNIVERSITYLocation SAN FRANCISCO, UNITED STATESPosted 1 Sept 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AffectAgingAlphaproteobacteriaBacteriaBacterial Antibiotic ResistanceBartonellaBehaviorBiochemicalBrucellaBypassC-terminalCarbonCell BodyCell DifferentiationCell Differentiation processCell membraneCellsClientCommunicable DiseasesCommunicationComplexCytoplasmic GranulesCytoplasmic MembraneDefectDevelopmentDiseaseDisorderE coliE. coliEnvironmentEscherichia coliEukaryotic CellExclusionExpression SignatureFabaceaeGammaproteobacteriaGene ExpressionGene Expression ProfileGeneticGenetic ModelsGoalsHealthHost DefenseHumanInfectionInfectious DiseasesInfectious DisorderInvadedInvestigationKnowledgeLegumesLeguminosaeLeguminoseaeLinkLiquid substanceLong-term infectionMedicago truncatulaMembraneMessenger RNAMicrobeMicroscopyMinorModelingModern ManMolecularNamesNerve DegenerationNeuron DegenerationNitrogenNitrogen FixationNoduleNon-Polyadenylated RNANutrientOrganellesOrganismPathogenesisPathway interactionsPhasePhysical condensationPlantsPlasma MembranePlayPreparationPreventionProcessProductivityPropertyProteinsRNARNA DecayRNA DegradationRNA Gene ProductsRNA NucleasesRNA ProcessingRNA metabolismRNaseRNase EReporterResearchResearch TrainingRhizobium melilotiRibonuclease Family ProteinRibonucleasesRibonucleic AcidRibonucleoproteinsRibosomal RNARickettsiaRickettsialesRochalimaeaRoleS melilotiS. melilotiScientific Advances and AccomplishmentsShapesSinorhizobium melilotiStructureStudentsSymbiosisSystemTransfer RNATranslatingTriplet Codon-Amino Acid Adaptoralpha Proteobacteriaantibiotic resistant bacteriabacterial antibiotic resistantbacterial resistance to antibioticcareercellular differentiationchemical reactionchronic infectioncommensalismcondensationdevelopmentalendonucleaseexperienceflexibilityflexiblefluidgamma Proteobacteriagene expression patterngene expression signaturegenetic analysisglobal gene expressionglobal transcription profilegranulehost colonizationhost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionshuman pathogenimprovedinsightintermolecular interactionliquidliving systemmRNAmRNA Decaymembrane structuremicrobialmicrobial diseasemutantnamenamednamingneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationpathogenpathwaypea familypersistent infectionplasmalemmapreparationspreventpreventingrRNAribonuclease Escaffoldscaffoldingscientific accomplishmentsscientific advancessocial rolestress granuletRNAtranscriptional profiletranscriptional signaturetranscriptometransfer Ribonucleic acidsγ-Proteobacteria
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Project Summary / Abstract
The proposed project will elucidate how subcellular compartmentalization of the RNase E

endonuclease into bacterial ribonucleoprotein granules (BR-bodies) in Sinorhizobium meliloti contributes to

successful host colonization. S. meliloti serves as a model for investigating infection by alpha-proteobacteria,

which…

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