grant
Near patient detection of pathogenic candida species directly from blood and urine for rapid treatment response
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AllelesAllelomorphsAmBAmBisomeAmphocilAmphotecAmphotercin BAmphotericin BAssayAutomationBioassayBiological AssayBloodBlood CirculationBlood Reticuloendothelial SystemBlood SampleBlood TestsBlood VolumeBlood specimenBloodstreamC albicansC aurisC. Auris resistanceC. albicansC. aurisC. glabrataC.albicansCandidaCandida albicansCandida aurisCandida glabrataClinicalClinical TrialsCodeCoding SystemCollaborationsCommunicable DiseasesDNA SequenceDetectionDevelopmentDiagnosisDiagnostic testsDrug TargetingDrug resistanceFibrinFungal Drug ResistanceFungizoneFungus DiseasesFungus drug resistantHematologic TestsHematological TestsHematology TestingHot SpotImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIndividualInfectionInfection ControlInfectious DiseasesInfectious DisorderLaboratoriesLifeMagnetic ResonanceMedical Care CostsMethodsMolecularMoniliaMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMycosesMysteclin-FNested PCRNested Polymerase Chain ReactionNucleic AcidsPathogenicityPatient CarePatient Care DeliveryPatientsPerformancePredispositionPreparationProcessReactionReagentReflexReflex actionReportingResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugRiskSamplingSensitivity and SpecificitySpecificitySusceptibilityTechnologyTemperatureTestingTherapeutic FungicidesTimeTorulopsis glabrataTrainingUnited StatesUrinary tract infectionUrinary tract infectious diseaseUrineValidationVirulentamplification and detectionamplification detectionanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantbasebasesblood infectionbloodstream infectioncandidaemiacandidemiacare for patientscare of patientscaring for patientsclinical relevanceclinical validationclinically relevantdetection assaydetection of amplificationdevelopmentaldiagnostic assaydrug resistantechinocandin resistanceechinocandin resistanteffective therapyeffective treatmentexperiencefungal infectionfungal pathogenfungi pathogenfungus drug resistancefungus infectionimmunosuppressed patientimprovedinfection in the bloodinfection of the bloodinnovateinnovationinnovativemedical costsmedical expensesmeltingmortalitymulti-drug resistantmultidrug resistantnew approachesnovel approachesnovel strategiesnovel strategypathogenic funguspoint of carepoint-of-care diagnosticspre-clinical studypreclinical studypreparationsrapid detectionrapid diagnosisrapid methodrapid techniqueresistance development in C. Aurisresistance in C. aurisresistance in Candida aurisresistance to Drugresistance to anti-fungalresistantresistant Candida aurisresistant to Drugresistant to anti-fungalresponse to therapyresponse to treatmenttesting accesstherapeutic responsetherapy responsetreatment responsetreatment responsivenessurinary infectionuser-friendlyvalidations
Description preview
ABSTRACT
Fungal species are among the most common causes of nosocomial bloodstream and invasive infections in
immunocompromised hosts. Mortality from candidemia can be very high, ranging from 20-40%. The global
emergence of virulent multidrug resistant species such as Candida auris, with a mortality reported to be as high
as 68% is particularly…
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