grant
NDRGs as mediators of hypoxia adaptation
Organization UNIVERSITY OF MARYLAND BALTIMORE COUNTYLocation BALTIMORE, UNITED STATESPosted 1 Jul 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026Active OxygenAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAdenosine TriphosphateAdenylpyrophosphateAerobicAgeAmericanAnoxiaApoplexyAreaBaltimoreBindingBiologyBrachydanio rerioBrain Vascular AccidentCause of DeathCell AnoxiaCell BodyCell Communication and SignalingCell DeathCell HypoxiaCell Membrane PermeabilityCell RespirationCell SignalingCell membraneCellsCellular AnoxiaCellular HypoxiaCellular RespirationCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCountyCytoplasmic MembraneDanio rerioDeathDegenerative Neurologic DisordersDevelopmentDiabetes MellitusDiseaseDisorderDown-RegulationDropsyEdemaElectron TransportEmbryoEmbryonicEndosomesEnvironmentEventExposure toFacultyGenesGoalsHb SS diseaseHbSS diseaseHealthHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderHumanHydropsHypoxiaHypoxicIn SituInjuryInstitutionalizationIntracellular Communication and SignalingIon TransportIonsKidneyKidney Urinary SystemLabelLaboratoriesLifeLiteratureMYCN ProteinMarylandMediatingMediatorMetabolicModelingModern ManMolecular InteractionN-Myc ProteinNMYC Gene ProductNa pumpNa(+)-K(+)-Exchanging ATPaseNa+ K+ ATPaseNaN3Nervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeuroblastoma MYCNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNormal RangeNormal ValuesO elementO2 elementOrganismOxygenOxygen DeficiencyOxygen RadicalsPathologyPathway interactionsPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPlasma MembranePositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPotassium ATPase SodiumPotassium Adenosinetriphosphatase SodiumPotassium PumpPredispositionPreventionPro-OxidantsProcessProductionProtein ModificationProtein TraffickingProteinsPublicationsPublishingPumpReactive Oxygen SpeciesReceptosomesRenal CellRenal functionResearchResearch TrainingRoleSTEM classSTEM courseSTEM disciplineSTEM fieldSTEM majorScientific PublicationServicesSickle Cell AnemiaSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSocietiesSodium AzideSodium PumpSodium-Potassium PumpStrokeStudentsSusceptibilityTestingTherapeuticTrainingTraining ProgramsTransferable SkillsUnderrepresented GroupsUnderrepresented PopulationsUnderrepresented StudentsUniversitiesVesicleWomanWorkZebra DanioZebra FishZebrafishacute kidney injuryadapter proteinaerobic metabolismaerobic respirationagesbiological signal transductionbrain attackcareer preparationcareer readinesscerebral vascular accidentcerebrovascular accidentchronic kidney diseaseconferenceconventiondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiabetesdoctoral studentelectron transferevidence baseexperimentexperimental researchexperimental studyexperimentsimpaired pulmonary vascularizationimprovedinjuriesjob readinesskidney cellkidney functionknowledge translationliving systemlung vascular diseasemembermembrane permeabilitymetabolic ratemodel organismmutantnecrocytosisneurodegenerative illnessnoveloxidative metabolismpathwayplasmalemmapreservationpreventpreventingprogramsprotein transportpulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vasculopathyrecruitrenalresponsescience, technology, engineering and math classscience, technology, engineering and math coursescience, technology, engineering and math disciplinescience, technology, engineering and math fieldscience, technology, engineering and math majorscience, technology, engineering and mathematics classscience, technology, engineering and mathematics coursescience, technology, engineering and mathematics disciplinescience, technology, engineering and mathematics fieldscience, technology, engineering and mathematics majorsickle cell diseasesickle cell disordersickle diseasesicklemiasocial rolesodium potassium exchanging ATPasestrokedstrokessummitsymposiasymposiumtraffickingtranslational opportunitiestranslational potentialunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunder served communityunderrepresentation of groupsunderrepresented peopleunderserved communitywork readinessworkforce readinessworkplace readiness
Description preview
PROJECT SUMMARY
Oxygen is essential for the life of many organisms, as it used during aerobic respiration to generate cellular
energy in the form of adenosine triphosphate (ATP). Low oxygen (whether caused by environmental or cellular
hypoxia) prevents adequate ATP production and can consequently cause cell death. Paradoxically, excessive
oxygen,…
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