grant
Narrowing the mechanistic gap for anterior prefrontal cortex function
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 9 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnteriorArchitectureAreaAttentionAuditoryBrainBrain Nervous SystemBrain imagingBrain regionCognitionCognition DisordersCognitiveComplexDWI (diffusion weighted imaging)DWI-MRIData SetDecision MakingDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDysfunctionEarly DiagnosisEarly identificationEncephalonEngineering / ArchitectureEvaluationFiberFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderHistologicHistologicallyHumanImageImaging technologyImmediate MemoryIndividualInvestigationLabelLateralLifeLinkLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMental HealthMental HygieneMental disordersMental health disordersMethodologyMethodsMicroscopicMissionModalityModern ManModernizationMonitorMorphologyNIMHNMR ImagingNMR TomographyNational Institute of Mental HealthNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurodevelopmental DisorderNeurological Development DisorderNeurosciencesNomenclatureNuclear Magnetic Resonance ImagingOutputParietal LobeParticipantPatientsPerformancePhysiopathologyPlayPositionPositioning AttributePrefrontal CortexProcessPsychiatric DiseasePsychiatric DisorderPsychological HealthRecurrenceRecurrentRegional AnatomyResearchResolutionRoleRunningSchizophreniaSchizophrenic DisordersSemanticsSensoryShort-Term MemoryStimulusStructureTechnologyTemporal LobeTerminologyTestingThinkingTimeVisualVisuospatialWorkZeugmatographyadulthoodbrain visualizationcerebral blood volumecognitive abilitycognitive diseasecognitive disordercognitive syndromecognitive taskdMRIdata sharingdementia praecoxdiffuseddiffusesdiffusingdiffusion tensor imagingdiffusionsearly detectionexperiencefMRIhigh resolution imagingimage-based methodimagingimaging methodimaging modalityimprovedindividual heterogeneityindividual variabilityindividual variationinnovateinnovationinnovativeinnovative technologiesinsightmemory retrievalmental illnessmental representationmental setmodel of animalmulti-modalitymulti-taskmultimodalitymultitaskneuralneural mechanismneurodevelopmental diseaseneuromechanismnovelparietal cortexpathophysiologypsychiatric illnesspsychological disorderresolutionsresponseschizophrenicsocial rolespecies differencesubstantia albatemporal cortextheoriesthoughtsvisual spatialwhite matterworking memory
Description preview
PROJECT SUMMARY
Prefrontal cortex (PFC) is a large and heterogeneous brain area comprising the front third of the human brain
that has been implicated in numerous mental health disorders. One of the least-studied subregions of PFC is
anterior lateral PFC (aLPFC). This region, whose functioning is impacted in disorders like schizophrenia, has
been…
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