grant
Nano Immune-Imaging Core
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 3 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AddressAdoptive TransferAgingAlloantigenArtificial nano particlesArtificial nanoparticlesB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBehaviorBindingBiologyBiomedical EngineeringBlood VesselsBody TissuesCD154CD40LCD40LGCD62L AntigensCardiac TransplantationCell BodyCell Communication and SignalingCell SignalingCellsChargeClinical Treatment MoabColoring AgentsConjugated CarrierDataDendritic CellsDepositDepositionDimensionsDrug DeliveryDrug Delivery SystemsDrug TargetingDrugsDyesEncapsulatedExocytosisGlycoproteinsGoalsGraft RejectionHeart GraftingHeart TransplantationHigh Endothelial VenuleHome for seniorsHomes for the AgedHomingImageImaging DeviceImaging InstrumentImaging ToolImmuneImmune Cell ActivationImmune RegulatorsImmune TargetingImmune ToleranceImmune mediated therapyImmune responseImmunesImmunityImmunologic ToleranceImmunologically Directed TherapyImmunomodulatorsImmunotherapeutic agentImmunotherapyIntracellular Communication and SignalingKineticsL-SelectinLAM-1LAM-1 Leukocyte Adhesion MoleculeLECAM-1Leu-8 AntigenLymph Node Reticuloendothelial SystemLymph node properLymphaticLymphatic cellLymphatic nodesLymphocyteLymphocyte Adhesion Molecule 1LymphocyticMedicationMel-14 AntigenMethodsModelingMolecularMolecular InteractionMonoclonal AntibodiesMouse StrainsNanodeliveryNatureOld Age HomesOrganPathogenesisPeripheralPharmaceutical PreparationsPhenotypePlayPropertyQuality ControlReactionRegulatory T-LymphocyteReticular CellRoleRouteSeriesShapesSignal TransductionSignal Transduction SystemsSignalingSiteStimulusStromal CellsSurfaceT memory cellT-CellsT-LymphocyteTNFSF5TNFSF5 geneTQ1 AntigenTRAP GeneTherapeuticTherapeutic UsesTissuesTonsilTransgenic MiceTransplant RejectionTransplantationTransplantation RejectionTransplantation ToleranceTregVeiled CellsVeinsVisualizationabsorptionagedaging associatedaging relatedallograft rejectionalloimmunityantibody conjugatebio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductioncardiac graftdrug/agentengineered nano particleengineered nanoparticlefiber cellheart transplanthome for elderlyhost responseimagingimaging studyimmune activationimmune drugsimmune imagingimmune modulatorsimmune system responseimmune system toleranceimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune unresponsivenessimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoimagingimmunologic therapeuticsimmunological paralysisimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimmunoresponseimmunotherapeuticsimmunotherapy agentin vivoinnovateinnovationinnovativeinsightinterestintradermal injectionintravenous injectionisoimmunitylymph celllymph glandlymph node microenvironmentlymph nodeslymphnodesmAbsmemory T lymphocytemigrationmonoclonal Absmultidisciplinarynanonano formulationnano medicinalnano medicinenano particlenano therapynano-sized particlenanoformulationnanomedicinalnanomedicinenanoparticlenanoproductsnanosized particlenanotherapynovelparticleprogramsregulatory T-cellsresponsesite targeted deliverysmall moleculesocial rolestemsurface coatingtargeted deliverythymus derived lymphocytetonsillartraffickingtransplantvascularvirtual
Description preview
CORE B - SUMMARY/ABSTRACT
Lymph nodes (LNs) play a pivotal role in regulating alloimmune responses. The overall goals of this core are (i)
to develop innovative nanodelivery strategies to reprogram the stroma of aged LNs and (ii) to carry out advanced
immune imaging for the homing of aged immune cells to the LNs and their interactions within the…
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