grant
Naive CD8 T cell functional heterogeneity
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 19 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20250-4 weeks old21+ years oldAdoptive TransferAdultAdult HumanAffectAgeAntigenic DeterminantsAntigensAreaAssayAtlasesAutoregulationBinding DeterminantsBioassayBiological AssayCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCell BodyCell divisionCellsCharacteristicsCollecting CellDataDevelopmentEffector CellEpitopesExhibitsExposure toGenerationsHLA Class I Histocompatibility Antigen, A-2 Alpha ChainHLA-A Class I Antigen 2HLA-A Histocompatibility Type Antigen 2HLA-A2HLA-A2 AntigenHeterogeneityHistoryHomeostasisHumanIFNImmune responseImmunityInfectionInflammationInterferonsMaintenanceMajor Histocompatibility Complex, Class I, A2 AntigenMalignant NeoplasmsMalignant TumorMemoryMethodsMiceMice MammalsModern ManMurineMusNewborn InfantNewbornsOperative ProceduresOperative Surgical ProceduresOutputParabiosisPeripheralPhenotypePhysiological HomeostasisPlayPopulationRecording of previous eventsResearchRoleSpecificitySplenectomySurgicalSurgical InterventionsSurgical ProcedureT cell responseT memory cellT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT-cell receptor repertoireT8 CellsT8 LymphocytesTCR repertoireTestingThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTransgenic MiceTransgenic OrganismsVaccinationVaccinesYellow fever virusadult youthadulthoodage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage groupage induced alterationsage induced changesage related alterationsage related changesage specific alterationsage specific changesagedagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with agechanges with agecohortdevelopmentalexhaustexperienceexperimentexperimental researchexperimental studyexperimentshistorieshost responseimmune system responseimmunogenimmunoresponseimprovedinflammatory environmentinflammatory milieulife spanlifespanmalignancymemory T lymphocytemultiomicsmultiple omicsneo-antigenneo-epitopesneoantigensneoepitopesneoplasm/cancernew approachesnewborn childnewborn childrennovel approachesnovel strategiesnovel strategypanomicspathogenpreventpreventingresponsesocial rolesurgerythymus derived lymphocytetime usetransgenictumorvirtualyoung adultyoung adult ageyoung adulthood
Description preview
Project Summary
There has been considerable progress in identifying subsets in effector, memory, and exhausted CD8 T cells,
and our understanding of the role of each subset in response to infection has greatly improved. However, much
less is known about the heterogeneity of naïve CD8 T cells, the predecessors of these antigen-experienced T
cells.…
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