grant
Myopia and Glaucoma, Linked via Mechanotransduction Mechanisms Affecting the Ganglion Cell Complex
Organization STATE COLLEGE OF OPTOMETRYLocation NEW YORK, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AccelerationAcuteAddressAffectAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesApoplexyArchitectureAstrocytesAstrocytusAstrogliaBlindnessBody TissuesBrain Vascular AccidentCausalityCell BodyCell Communication and SignalingCell CountCell FunctionCell NumberCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeComplexConnexin 43Connexin43CouplingCx43DataDetectionDevelopmentDiagnosisDiminished VisionDrug TherapyDysfunctionEarly identificationEngineering / ArchitectureEpidemicEpidemiologistEtiologyExhibitsExperimental TherapiesExposure toEyeEyeballFunctional disorderGeneralized GrowthGeneticGenetic MarkersGlaucomaGliaGlial CellsGoalsGrowthHealth Care ProfessionalHealth ProfessionalHortega cellHumanImpairmentIndividualIntracellular Communication and SignalingInvestigational TherapiesInvestigational TreatmentsKolliker's reticulumLeannessLinkLow VisionMasksMechanical Signal TransductionMechanical StressMechanicsMechanosensory TransductionMicrogliaMissionModern ManMolecularMyopiaNHP modelsNatureNearsightednessNeurogliaNeuroglial CellsNeuropathyNon-neuronal cellNonneuronal cellOptic DiskOptic Nerve HeadOptic PapillaOutcomePartial SightPatientsPatternPerceptionPharmacological TreatmentPharmacotherapyPhysiopathologyPopulationPredispositionPrevalencePreventative strategyPrevention strategyPreventive strategyProgressive MyopiaPublic HealthQOL improvementReduced VisionResearchRetinal Ganglion CellsRiskScientistSecondary toSightSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmokerStretchingStrokeSubcellular ProcessSubnormal VisionSusceptibilityTestingTherapeuticThickThicknessThinnessTimeTissue GrowthTissuesVisionVisual impairmentastrocytic gliaaxon damageaxon injuryaxonal damageaxonal degenerationaxonal injurybiological signal transductionbrain attackcardiovascular disease riskcardiovascular disorder riskcausationcerebral vascular accidentcerebrovascular accidentdegenerative axondevelopmentaldiagnostic approachdiagnostic biomarkerdiagnostic markerdiagnostic strategydisease causationdrug interventiondrug treatmentearly biomarkersearly detection biomarkersearly detection markersexperienceexperimental therapeutic agentsexperimental therapeuticsgangliocyteganglion cellgene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkergitter cellglaucomatousglial activationglial cell activationhypertensiveimprovements in QOLimprovements in quality of lifeinnovateinnovationinnovativemechanicmechanicalmechanical stimulusmechanosensingmechanotransductionmesogliamicroglial cellmicrogliocytemodel of animalnear visionnerve cementneuropathicneuroprotectionneuroprotectivenon-human primatenonhuman primatenonhuman primate modelsnovelontogenypathophysiologyperivascular glial cellpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspressurepreventpreventingquality of life improvementresponseretinal ganglionstressorstrokedstrokestherapeutic targettooltreatment strategyvision impairmentvision lossvisual functionvisual lossvisually impaired
Description preview
Project Summary/Abstract
Public perception of myopia as a simple inconvenience masks its sight-threatening
consequences. Even moderate levels of myopia predispose an individual to glaucoma at rates
equal to a hypertensive's risk for cardiovascular disease. Yet, we lack specific diagnostic markers
to identify glaucoma in myopic patients. In fact,…
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