grant
Myeloid-derived suppressor cells modulate disease severity in children with viral lower respiratory tract infections
Organization RESEARCH INST NATIONWIDE CHILDREN'S HOSPLocation COLUMBUS, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years old5 year old5 years of ageAdmissionAdmission activityAdultAdult HumanAgeAllogenicAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntineoplastic VaccineApoptoticApplications GrantsAutoregulationB7-H1Blood SampleBlood granulocytic cellBlood monocyteBlood specimenCD274CD28CD28 geneCD3CD3 AntigensCD3 ComplexCD3 moleculeCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID-19CV-19Cancer VaccinesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCause of DeathCell BodyCell CountCell FunctionCell NumberCell PhysiologyCell ProcessCell surfaceCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeCharacteristicsChildChild YouthChildhoodChildren (0-21)ClinicalClinical DataClinical ResearchClinical StudyClinical TrialsCo-cultureCocultivationCocultureCoculture TechniquesComputerized Medical RecordCoronavirus Infectious Disease 2019Critical CareCritical IllnessCritically IllCritically ill childrenDataDeathDevelopmentDiseaseDisorderElectronic Medical RecordEnrollmentExperimental DesignsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesFutureGoalsGrant ProposalsGranular LeukocytesGranulocytic cellHLA-BRHLA-BR AntigensHLA-D-Related AntigensHLA-DRHLA-DR AntigensHLA-MTHLA-MT AntigensHomeostasisHospital AdmissionHospital InfectionsHospital acquired infectionHospitalizationHourImmuneImmune Modulation TherapyImmune MonitoringImmune responseImmunesImmunobiologyImmunochemical ImmunologicImmunologicImmunologic MonitoringImmunologic SubtypingImmunologicalImmunological MonitoringImmunologicallyImmunologicsImmunomodulationImmunomonitoringImmunophenotypingImmunophysiologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIn VitroInduction of ApoptosisInflammatoryInvestigationK-AwardsK-Series Research Career ProgramsKnowledgeLiteratureLower Respiratory Tract InfectionLower respiratory infectionLymphatic cellLymphocyteLymphocyte SubpopulationsLymphocyte SubsetLymphocyticMarrow monocyteMeasuresMediatingMentorsMyeloid-derived suppressor cellsNeoplasm VaccinesNosocomial InfectionsOKT3 antigenObservation researchObservation studyObservational StudyObservational researchOncologyOncology CancerOutcomePBMCPD 1PD-1PD-1 blockadePD-1 checkpoint pathwayPD-1 pathwayPD-1 signaling pathwayPD-L1PD1PD1 blockadePD1 checkpoint pathwayPD1 pathwayPD1 signaling pathwayPDL-1Pathway interactionsPatient SelectionPatientsPeripheral Blood Mononuclear CellPhenotypePhysiciansPhysiological HomeostasisPlayPopulationProductionProductivityProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1Regulatory T-LymphocyteReportingResearchResearch Career ProgramRiskRoleSamplingScientistSeptic ShockSeverity of illnessStaining methodStainsStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationSubcellular ProcessSupportive TherapySupportive careT-Cell ProliferationT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT3 AntigensT3 ComplexT3 moleculeT4 CellsT4 LymphocytesT44T8 CellsT8 LymphocytesTestingTrainingTreatment ProtocolsTreatment RegimenTreatment ScheduleTregTumor BurdenTumor LoadTumor VaccinesViralViral Respiratory Tract InfectionVirusWorkadaptive immune responseadulthoodage 5 yearsagesanti programmed cell death protein 1 checkpoint pathwayanti programmed cell death protein 1 pathwayanti programmed cell death protein 1 signaling pathwayanti-PD-1 blockadeanti-PD1 blockadeanti-tumor vaccinecareercell agecellular agechemotherapycoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19critically ill childcytokinedeath riskdesigndesigningdevelopmentaldisease severityenrollexperienceexperimentexperimental researchexperimental studyexperimentsfightingfive year oldfive years of ageflow cytophotometrygranulocytehost responseimmune modulationimmune modulatory therapiesimmune modulatory treatmentimmune regulationimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune-modulation treatmentimmunologic reactivity controlimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatoryimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulationimmunoregulatoryimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive myeloid cellsimmunosuppressive responseimprovedimproved outcomein vitro Modelinhibitorinstitutional infectionkidslife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2lymph cellmagnetic beadsmonocytemortalitymortality riskmyeloid suppressor cellsmyeloid-derived suppressive cellsnovelpathogenic viruspathwaypatient centeredpatient orientedpediatricperipheral bloodpressureprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein ligand 1programmed death 1programsprospectiveprotein death-ligand 1regulatory T-cellsrespiratoryscRNA sequencingscRNA-seqserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2single cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2social rolestatistical analysissuppressive myeloid cellssystemic lupus erythematosus susceptibility 2therapeutic immunomodulationtherapeutic immunoregulationtherapeutic targetthymus derived lymphocytetoolvaccine for cancervasoactive agentviral pathogenviral respiratory infectionvirus pathogenwardyoungster
Description preview
Project Summary
Severe lower respiratory tract infection (LRTI) due to viral pathogens remains one of the most common causes
of death for young children worldwide. Current management of patients with viral-induced LRTI focuses on
supportive care, but outcomes may be improved by augmenting the host immune response to fight the virus and
regain…
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