grant

Muscular Dystrophy Specialized Research Center

Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 8 Jun 2005Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AccelerationActive Follow-upAdvisory CommitteesAffectBasic ResearchBasic ScienceBindingBiopsyBody TissuesCell BodyCell Culture TechniquesCellsChildhoodClinicalClinical ResearchClinical SciencesClinical StudyClinical TrialsClinical Trials DesignCollaborationsCommunicationCommunitiesCommunity OutreachCraninCryofixationCryopreservationDevelopmentDiagnosisDiagnosticDiagnostic testsDisciplineDysfunctionDystroglycanEducationEducational aspectsElectroretinographyEnvironmentExclusionFKRPFamilyFellowshipFibroblastsFosteringFunctional disorderFundingGenesGenotypeGlycoprotein GP-2GoalsHuman ResourcesIndividualInfrastructureInvestigatorsIowaLGMD2ILaboratoriesLamininLengthLimb-Girdle Muscular DystrophiesMD studentsManpowerMeasuresMedical StudentsMentorsMentorshipMiceMice MammalsMissionMolecularMolecular InteractionMotorMotor ManifestationsMurineMusMuscleMuscle TissueMuscle functionMuscular DystrophiesMyodystrophicaMyodystrophyNational Institutes of HealthNatural HistoryNeuromuscular DiseasesNeuromuscular researchPathologyPatient CarePatient Care DeliveryPatientsPediatric NeurologyPhysiopathologyPostdocPostdoctoral FellowProteinsProteomicsReceptor ProteinRegulationResearchResearch AssociateResearch PersonnelResearch ResourcesResearch TrainingResearchersResource SharingResourcesRespiratory MusclesRespiratory physiologySkeletal MuscleSpecialtyStudentsTask ForcesTestingTissuesTrainingTranslational ResearchTranslational ScienceTranslationsUnited States National Institutes of HealthUniversitiesUrineVentilatory MusclesVoluntary MuscleWorkactive followupadvanced diseaseadvanced illnessadvisory teambiobankbiomarker discoverybiorepositorycare for patientscare of patientscaring for patientscell culturecell culturescell repositorycellular repositorychild neurologyclinical careclinical translationclinically translatableco-morbidco-morbiditycohortcold preservationcold storagecomorbidityconferenceconventiondepositorydevelopmentaldystroglycanopathyelectroretinogramfollow upfollow-upfollowed upfollowupfukutin related proteingraduate studentimprovedinterestlimb-girdle muscular weakness and atrophylimb-girdle syndromemedical school studentsmedical specialtiesmembermouse modelmurine modelmuscle dystrophymuscularmyoneural disordermyopathic limb-girdle syndromeneuromuscularneuromuscular degenerative disorderneuromuscular disordernext generationnovelparticipant engagementpathophysiologypatient engagementpediatricpersonnelpost-docpost-doctoralpost-doctoral traineepotential biological markerpotential biomarkerpre-clinicalpre-clinical researchpreclinicalpreclinical researchprogramsreceptorreceptor functionrecruitrepositoryresearch associatesrespiratoryrespiratory functionskeletal muscle weaknesssummitsymposiasymposiumtissue culturetissue/cell culturetranslationtranslation researchtranslational investigationundergradundergraduateundergraduate researchundergraduate studentuser-friendlyweb sitewebsiteyounger ageα-DGα-DystroglycanαDG
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Description preview

OVERALL SUMMARY
The overall goal of the University of Iowa Wellstone Muscular Dystrophy Specialized Research Center

(MDSRC) is to perform research on muscular dystrophies (called dystroglycanopathies) that arise from

absence or reduction in matriglycan on α-dystroglycan (α-DG). Dystroglycanopathies are a group of

congenital/limb-girdle muscular…

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