grant
Murine models of vascular remodeling
Organization NATIONAL HEART, LUNG, AND BLOOD INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025ASCVDAccelerationAcuteAffectAngiogenesis FactorAngiogenic FactorAngioplastyAortocoronary BypassArterial InjuryArteriesAssayAtherosclerosisAtherosclerotic Cardiovascular DiseaseBioassayBiological AssayBlood VesselsBlood capillariesBody TissuesBone-Derived Transforming Growth FactorCapillarityCell BodyCell Communication and SignalingCell Culture TechniquesCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCell-Extracellular MatrixCellsCellular ProliferationClinicalClosure by LigationCompensationComplexCoronary Artery BypassCoronary Artery Bypass GraftingCoronary Artery Bypass SurgeryCoronary arterial bypassCromolyn SodiumDNA mutationDefectDevelopmentDiabetes MellitusDiseaseDisodium CromoglycateDisorderDrug TargetingDrugsDysembryomaDysplasiaECMEarly DiagnosisEffectivenessEndothelial CellsEndotheliumEnvironmentEventExtracellular MatrixFaithFibroblastsFibrosisGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGranulation TissueGrowthHIF 1HIF 1 alphaHIF-1 proteinHIF-1alphaHIF1HIF1 proteinHIF1-AlphaHIF1AHIF1A geneHIF1αHindlimbHumanHyper-IgE SyndromeHyperimmunoglobulin E SyndromeHyperimmunoglobulin E-Recurrent Infection SyndromeHyperplasiaHyperplasticImmune infiltratesImmune responseImmunodeficient MouseIn VitroInflammationInflammatoryInflammatory ResponseInjectionsInjuryIntalInterventionIntracellular Communication and SignalingIschemiaJob's SyndromeKnock-outKnockoutLeiomyocyteLigationLineage TracingLinkLung DiseasesMOP1Marrow Mast CellMast Cell StabilizerMedialMediatingMediatorMedicationMesenchymalMiceMice MammalsMilk Growth FactorModelingModern ManMorphologyMurineMusMuscleMuscle TissueMutationNasalcromOutcomePathologicPathologyPathway interactionsPatientsPerioperativePharmaceutical PreparationsPhasePhenotypePhosphorylationPhysiologyPlatelet Transforming Growth FactorPlayPostoperativePostoperative PeriodProceduresProcessProgenitor CellsPropertyProtein PhosphorylationPulmonary DiseasesPulmonary DisorderRoleSTAT3STAT3 geneSTAT3 loss of functionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSkin wound healingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSodium CromoglycateSplint DeviceSplintsStentsStructural defectStructural malformationStructureSubcutaneous InjectionsSystemTGF BTGF-betaTGF-βTGFbetaTGFβTeratoid TumorTeratomaTestingThrombosisTissue BasophilsTissue GrowthTissuesTopical Drug AdministrationTopical applicationTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTubeVascular DiseasesVascular DisorderVascular calcificationVascular remodelingVein graftVeinsWound RepairWound modelsangiogenesisapply topicallyarterial remodelingatheromatosisatherosclerotic diseaseatherosclerotic vascular diseaseautosomebiological signal transductionblood perfusionblood vessel disordercapillarycell culturecell culturescell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingclinical relevanceclinically relevantcoronary bypasscutaneous wound healingdeliver topicallydensitydermal wound healingdevelopmentaldiabetesdisease of the lungdisorder of the lungdrug/agentdyscrasiaearly detectionendothelial dysfunctionfemoral arterygenome mutationgraft failurehealinghost responsehypoxia inducible factor 1iPSiPSCiPSCsimmune cell infiltrateimmune system responseimmunoresponseimprovedin vivoin vivo Modelinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinjuriesintraluminal angioplastylung disordermast cellmastocytemouse modelmurine modelmuscularnovelontogenypathwaypercutaneous coronary interventionpreventpreventingrestenosisrestorationrevascularizationslugsocial rolestem cellsstructural abnormalitiesstructural anomaliessubdermal injectiontherapeutic targetthrombotic diseasethrombotic disordertissue woundtopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttreat topicallytreat woundvascularvascular abnormalityvascular dysfunctionvascular smooth muscle cell migrationvasculopathyvein occlusionwoundwound closurewound healingwound healing modelswound managementwound recoverywound resolutionwound therapeuticswound therapywound treatmentwoundingwounds
Description preview
Vascular remodeling, a common process in many vascular diseases, describes morphological changes within the vascular wall and adjacent perivascular structures. Inflammation, endothelial dysfunction, and vascular smooth muscle cell migration and proliferation are main factors triggering this process, which may lead to neointimal hyperplasia, medial…
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