grant
Multivalent mRNA-based malaria vaccines
Organization DREXEL UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20250-11 years oldAddressAdjuvantAdvanced DevelopmentAntibodiesAntibody titer measurementAntigenic DeterminantsAntigensAreaAutomobile DrivingBindingBinding DeterminantsBinding ProteinsBlocking AntibodiesBloodBlood Reticuloendothelial SystemBlood erythrocyteBlood reticulocyteC-terminalCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCarrier ProteinsCell BodyCellsCessation of lifeChildChild YouthChildren (0-21)ClinicalDataDeathDevelopmentDiffusely basophilic erythrocyteDiseaseDisorderDrug TherapyEpitopesErythrocytesErythrocyticEvaluationFormulationFoundationsGametesGerm CellsGerm-Line CellsHepatic CellsHepatic Parenchymal CellHepatocyteHomologous ProteinImmune responseImmunizationImpairmentIndividualInternationalInvadedLeftLigand Binding ProteinLigand Binding Protein GeneLiverLiver CellsMSA-1MSA-1 ProteinMSA1MSA1 ProteinMSP-1MSP1Major Merozoite Surface Protein PrecursorMalariaMalaria VaccinesMalaria preventionMalarial VaccinesMammalian CellMarrow erythrocyteMarrow reticulocyteMediatingMerozoite Surface Antigen 1Merozoite Surface Protein 1Messenger RNAModificationMolecular InteractionN-terminalNH2-terminalNatureP DomainP falciparumP-Type DomainP. falciparumP.falciparumPFM-PSCPPMMSAPaludismParasitesPeptide DomainPharmacological TreatmentPharmacotherapyPlasmodiumPlasmodium InfectionsPlasmodium falciparumPlasmodium falciparum Merozoite Precursor Surface Coat ProteinPlasmodium vivax MalariaPlasmodium yoeliiPolychromatophilic ErythrocytePolyvalent VaccinePopulationPredispositionProductionProtein BindingProtein DomainsProtein HomologProteinHomologRNA vaccineRNA-based vaccineRecombinantsRed Blood CellsRed CellRegulatory approvalReportingReproductive CellsResearchReticulocytesSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSafetySevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSex CellSporozoitesSubunit VaccinesSusceptibilityT cell responseT8 CellsT8 LymphocytesTFF DomainTechnologyTertiary Protein StructureTestingTherapeuticTimeTransport Protein GeneTransport ProteinsTransporter ProteinTrefoil MotifVaccination acquired immunityVaccination induced immunityVaccine AntigenVaccine DesignVaccinesVivax MalariaWorkantibody titeringblood corpusclesbound proteinburden of diseaseburden of illnesscell mediated immune responsecircumsporozoite proteincoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccs proteindesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldisease burdendrivingdrug interventiondrug treatmentexperiencehepatic body systemhepatic organ systemhost responsehuman subjectimmune system responseimmunogenimmunogenicimmunogenicityimmunoresponseimprovedinitial cellkidsmRNAmRNA vaccinemRNA-based vaccinemerozoite surface proteinneutralizing antibodynovelpathogenic viruspharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprevent malariaprogramsprotein protein interactionrapid diagnosisregulatory authorizationregulatory certificationregulatory clearanceresponsesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsexual cellsuccesstoolvaccine acquired immunityvaccine associated immunityvaccine candidatevaccine developmentvaccine platformvaccine-induced immunityvaccine-induced protectionvaccines against malariavector controlvector mosquitoviral pathogenvirus pathogenyoungster
Description preview
The heavy burden of Plasmodium falciparum and Plasmodium vivax malaria drove international efforts
to coordinate and integrate tools and programs for mosquito vector control, rapid diagnosis, and drug treatment.
Success has been significant but may be approaching a limiting boundary. The effort to develop a vaccine to
further enhance malaria…
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