grant
Multisystem Stress Response Biotypes: Deriving Novel Physiological and Neural Risk Factors for Anhedonia in Adolescence
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 12 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202512-20 years oldAcuteAdolescenceAdolescentAdolescent YouthAdrenal GlandsAdrenalsAffective DisordersAgeAmmon HornAnhedoniaAutonomic nervous systemBiologicalBiological MarkersBuffersCalibrationCharacteristicsClinicalClinical assessmentsComplexCornu AmmonisDevelopmentDiagnosticEarly identificationEndocrineFoundationsFunctional MRIFunctional Magnetic Resonance ImagingGoalsHPA axisHippocampusHypophysisHypophysis CerebriHypothalamic structureHypothalamusImageIndividualInferiorInterventionIntervention StrategiesLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMajor Depressive DisorderMapsMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingMood DisordersNMR ImagingNMR TomographyNeurobiologyNuclear Magnetic Resonance ImagingOnset of illnessOutcomeParasympathetic Nervous SystemPatient Self-ReportPatternPhysiologicPhysiologicalPituitaryPituitary GlandPituitary Nervous SystemPreventative strategyPrevention strategyPreventive strategyPsychopathologyPsychosesPubertyQOLQuality of lifeResearchRiskRisk FactorsRoleSelf-ReportSeveritiesStressStress TestsSurvey InstrumentSurveysSympathetic Nervous SystemSystemTimeYouthYouth 10-21Zeugmatographyabnormal psychologyacute stressadolescence (12-20)agesbehavior testbehavioral testbio-markersbiologicbiologic markerbiological adaptation to stressbiomarkerbiotypesclinical depressionclinical predictorscognitive assessmentcognitive testingcritical developmental perioddevelopmentaldisabilitydisease onsetdisorder onsetexperiencefMRIfrontal cortexfrontal lobehippocampalhypothalamichypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisimagingindicators of resiliencejuvenilejuvenile humanlong-term studylongitudinal outcome studiesmajor depressionmajor depression disordermarker of biological resiliencemarkers underlying resiliencemood regulationmulti-modalitymultimodalityneuralneural circuitneural circuitryneural mechanismneurobiologicalneurobiological mechanismneurocircuitryneuromechanismnovelpleasureprogramsreaction; crisisresilience biomarkerresilience markerresponsesexsignatures of resiliencesocial rolestress reactivitystress responsestress; reactionstressorsuprarenal glandsymptomatologysynaptic circuitsynaptic circuitryyouth age
Description preview
PROJECT SUMMARY
Anhedonia (ANH), the reduced ability to anticipate or experience pleasure, is a major transdiagnostic contributor to
disability, inferior quality of life, and a core characteristic of multiple severe psychopathologies. ANH emerges in
adolescence prior to the onset of these disorders and is highly prevalent (up to 20%) in youth…
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