grant
Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology
NIHUS FederalResearch GrantFY2026AI language modelsAb-mediated immunityAb-mediated protectionAccelerationAddressAdoptedAffectAgeAirway mucosaAmino Acid SequenceAnti-viral ResponseAntibodiesAntibody DiversityAntibody RepertoireAntibody ResponseAntibody immunityAntibody protectionAntibody-mediated protectionAntigensAssayB cell receptorB-Cell Antigen ReceptorBehaviorBioassayBiologic ModelsBiological AssayBiological ModelsBiologyBody TissuesCalibrationCell BodyCellsCessation of lifeCharacteristicsClinicalClinical Treatment MoabCollectionComparative StudyComplexComputer ModelsComputerized ModelsDataData SetDeathDefense MechanismsDetectionDevelopmentDonor personDrynessEpithelial CellsEvolutionExposure toFlu vaccinationFoundationsGenerationsGeneticGoalsGrippeH1N1H1N1 VirusH3N2H3N2 VirusHeterogeneityHistoryHospital AdmissionHospitalizationHost FactorHost Factor ProteinHumanIgAImmuneImmune MonitoringImmune responseImmunesImmunoassayImmunobiologyImmunochemical ImmunologicImmunoglobulin AImmunologicImmunologic ModelImmunologic MonitoringImmunologicalImmunological ModelsImmunological MonitoringImmunologicallyImmunologicsImmunomodulationImmunomonitoringImmunophysiologyIn VitroIndividualInfectionInfluenzaInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza VaccinesInfluenza VirusInfluenza immunizationInfluenza vaccinationIntegration Host FactorsInvestigatorsLanguageLeadershipLeftLungLung ParenchymaLung Respiratory SystemLung TissueMessenger RNAModel SystemModelingModern ManMolecularMonoclonal AntibodiesMucosaMucosal TissueMucous MembraneOutcomePatientsPopulationPrimary Protein StructurePropertyProphylactic vaccination against influenzaProteinsQualifyingRecording of previous eventsResearch PersonnelResearchersRespiratory EpitheliumRespiratory MucosaSamplingScienceSeasonsSiteSourceStructureStructure of parenchyma of lungStructure of respiratory epitheliumT-CellsT-LymphocyteTimeTissuesTrainingTransformer language modelVaccinatedVaccinationVaccineeVaccinesVariantVariationViral BurdenViral LoadViral Load resultVirusVulnerable Populationsagedagesairway epitheliumanti-fluanti-influenzaantibody-mediated immunityantifluartificial intelligence language modelsbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiescell mediated immune responseco-morbidco-morbiditycohortcomorbiditycomparativecomputational modelingcomputational modelscomputational platformcomputer based modelscomputer based predictioncomputerized modelingcomputing platformcytokinedevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldirect applicationdynamic systemdynamical systememergent pandemicemerging pandemicevaluate vaccinesexperienceexperimentexperimental researchexperimental studyexperimentsflu immunisationflu infectionflu serotypeflu strainflu subtypeflu transmissionflu vaccineflu viral strainflu virus infectionflu virus pandemicflu virus strainflu virus vaccinegenerative modelshealthy volunteerhigh dimensionalityhistorieshost responsehuman datahuman subjectimmune modulationimmune regulationimmune system responseimmunogenimmunologic reactivity controlimmunological statusimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponsein silicoindexingindividual responseindividualized responseinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza serotypeinfluenza straininfluenza subtypeinfluenza transmissioninfluenza viral straininfluenza virus infectioninfluenza virus pandemicinfluenza virus straininfluenza virus vaccinationinfluenza virus vaccineinfluenzaviruslarge language modellarge scale language modelmAbsmRNAmassive scale language modelsmonoclonal Absmortalitymulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultiscale computational modelingmultiscale mathematical modelingmultiscale modelingneutralizing antibodynew pandemicnovel pandemicoutcome following vaccinationoutcome following vaccinepan influenza vaccinepan influenza viral vaccinepan influenza virus vaccinepandemic flupandemic influenzapandemic strain of influenzapathogenpolyclonal antibodyprediction algorithmpredictive modelingprogramsprotein protein interactionprotein sequencepsychological defense mechanismrespiratory tract epitheliumresponseresult following vaccinationresult following vaccinesexsimulationsolutespatial and temporalspatial temporalspatiotemporalthymus derived lymphocytetooltransmission of the flu virustransplant donoruniversal flu vaccineuniversal influenza vaccineuniversal influenza virus vaccineuniversal vaccine against fluuniversal vaccine against influenzavaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccination against influenzavaccination outcomevaccination resultvaccine against fluvaccine against influenzavaccine developmentvaccine efficacyvaccine evaluationvaccine outcomevaccine resultvaccine screeningvaccine testingvectorvulnerable groupvulnerable individualvulnerable people
Description preview
Seasonable inlfuenza A and B result in up to 500,000 deaths globally each year, and influenza pandemics
resulting form antigenic shifts have the potential to result in in orders of magnitude higher mortality. However,
seasonable influenza vaccines are only 10-60% effective, and are unlikely to provide any protection against
novel pandemic strains.…
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