grant
Multiscale Modeling of Hippocampus Vulnerability to Alzheimer's Disease Neurodegeneration.
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Jan 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3D65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD dementiaAD modelAD pathologyAD patientsAffectAged 65 and OverAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAmentiaAmmon HornAreaAtlasesAtrophicAtrophyAutopsyAxonBiologicalBrainBrain Nervous SystemBrain regionCell BodyCell DeathCellsCellular MorphologyCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalCommon Rat StrainsComplexComputer softwareCornu AmmonisDataData SetDegenerative Neurologic DisordersDementiaDendritesDevelopmentDiameterDiathesisDiseaseDisease ProgressionDisease susceptibilityDisorderDisturbance in cognitionElectrodesEncephalonEvolutionFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationFoundationsFutureGABA ReceptorGene ExpressionGene TranscriptionGenerationsGenesGenetic MarkersGenetic TranscriptionGlutamate ReceptorHippocampusHumanImpaired cognitionIndividualInvestigationIon ChannelIonic ChannelsKnowledgeLabelLengthMapsMembrane ChannelsMemoryMiceMice MammalsModelingModern ManMorphologyMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeuroendocrineNeuroendocrine SystemNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeurosecretory SystemsNon-linear DynamicNon-linear DynamicsNonlinear DynamicNonlinear DynamicsOutputPatternPersonsPopulationPredispositionPrimary Senile Degenerative DementiaProcessProgressive DiseasePropertyRNA ExpressionRabiesRatRats MammalsRattusResearchSocial BehaviorSoftwareSusceptibilitySymptomsSynapsesSynapticSystems TheoryTestingTherapeutic InterventionTissue SampleTracerTranscriptionViralWorkabove age 65after age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65alzheimer modelbiologicbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiescell morphologycell typeclinical predictorscognitive dysfunctioncognitive losscomputational frameworkcomputational network modelingcomputer frameworkconnectomeconnectome dataconnectomic datadegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldigitaldrug developmentgamma-Aminobutyric Acid Receptorsgene biomarkergene expression biomarkergene markergene panelgene signature biomarkergenetic biomarkerhippocampalhuman old age (65+)insightintervention therapyliability to diseaselyssamouse modelmulti-scale atlasmulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultigene panelmultiscale atlasmultiscale computational modelingmultiscale mathematical modelingmultiscale modelingmurine modelnecrocytosisnecropsynetwork dysfunctionnetwork modelsneuralneural degenerationneural networkneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationover 65 yearspatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADpostmortempostsynapticpresynapticpreventpreventingprimary degenerative dementiareconstructionsenile dementia of the Alzheimer typesociobehaviorsociobehavioralspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssuccesssynapsetherapeutic evaluationtherapeutic targettherapeutic testingthree dimensionaltranscriptomicstranslational applicationstreatment strategyvirtual≥65 years
Description preview
Project Summary/Abstract
Neurodegeneration of the hippocampus is believed to be associated with cognitive decline in patients
with Alzheimer’s disease (AD). Cognition is considered to be an emergent brain function resulting from neural
network level computation rather than individual cellular processing, but exactly how AD cognitive impairment…
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